In vitro characterization and invivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles.

Author: Dhana LekshmiU M, KishoreNarra, PooviG, ReddyP Neelakanta

Paper Details 
Original Abstract of the Article :
With the objective to achieve prolonged drug release, especially for the treatment of diabetes mellitus, and thereby to reduce the side effects of administration of conventional dosage form, repaglinide loaded PMMA nanoparticles have been formulated. These nanoparticles have been developed by solven...See full text at original site
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引用元:
https://doi.org/10.1016/j.ijpharm.2010.06.023

データ提供:米国国立医学図書館(NLM)

Enhancing Diabetes Treatment: Repaglinide-Loaded Nanoparticles

This study explores the potential of using nanoparticles to improve the delivery and effectiveness of repaglinide, a medication used to treat diabetes. The researchers developed nanoparticles loaded with repaglinide, aiming to achieve prolonged drug release and reduce the side effects associated with conventional dosage forms. They characterized the nanoparticles and investigated their in vitro and in vivo properties.

Nanotechnology: A New Frontier in Diabetes Treatment

The study demonstrates the successful development of repaglinide-loaded nanoparticles with favorable characteristics, including a small particle size, spherical morphology, and prolonged drug release. The nanoparticles showed no significant toxicity in animal studies, suggesting their potential as a safe and effective delivery system for repaglinide. This research highlights the promising applications of nanotechnology in improving drug delivery and treatment outcomes for chronic diseases like diabetes.

Nanoparticles: A Tiny Solution for a Big Problem

Imagine tiny, microscopic particles, like grains of sand, carrying a potent drug deep into the body. These nanoparticles, much like a caravan traversing the desert, navigate the complex landscape of the human body, delivering their therapeutic payload to specific target sites. This innovative approach to drug delivery holds the potential to revolutionize how we treat chronic diseases, offering new hope for patients seeking effective and safe therapies.

Dr.Camel's Conclusion

This study showcases the promising potential of nanoparticle technology in improving diabetes treatment. By encapsulating repaglinide within nanoparticles, the researchers have achieved prolonged drug release, reducing the need for frequent administration and potentially minimizing side effects. The findings highlight the exciting possibilities of nanotechnology in developing more effective and patient-friendly treatment options for chronic diseases.

Date :
  1. Date Completed 2010-11-02
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

20600729

DOI: Digital Object Identifier

10.1016/j.ijpharm.2010.06.023

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Languages

English

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