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Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.

Author: CarmanTeresa L, GripshoverBarbara M, HarrillDanielle E, HilemanCorrilynn O, McComseyGrace A, O'RiordanMaryann, StorerNorma J, WhiteCynthia A

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Salsalate, an anti-inflammatory agent, did not significantly improve endothelial function, inflammation, or coagulation markers in virologically suppressed HIV-infected adults on antiretrovirals. Tinnitus and transaminitis were frequent side effects.
Paper Details　
Original Abstract of the Article :
In this 13-week, open-label, randomized study of the anti-inflammatory salsalate versus usual care, there were no significant improvements in flow-mediated dilation of the brachial artery, endothelial activation, inflammation or coagulation markers, homeostasis model assessment of insulin resistance...See full text at original site
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引用元：
https://doi.org/10.1097/QAD.0b013e32833c3251

データ提供：米国国立医学図書館（NLM）

Salsalate: A Disappointing Result for Endothelial Function in HIV-Infected Individuals

The quest for effective treatments for HIV-infected individuals continues, a relentless journey through a complex and often harsh landscape. This study delves into the potential of salsalate, an anti-inflammatory drug, to improve endothelial function in virologically suppressed HIV-infected adults. Like a lone explorer searching for a hidden oasis, this study aimed to see if salsalate could offer a refuge from the detrimental effects of HIV.

The results, however, were a disappointment, like finding a dry well in the desert. Salsalate failed to show any significant improvements in endothelial function, inflammation, or coagulation markers. Furthermore, the study found that salsalate was poorly tolerated, with frequent occurrences of tinnitus and transaminitis, making it difficult to navigate the treatment landscape.

Salsalate Fails to Deliver on Promise

Despite hopes for a beneficial effect on endothelial function, salsalate did not live up to expectations. The study found no significant improvements in endothelial function, inflammation, or coagulation markers, leaving researchers with a desert of unanswered questions.

Navigating the Side Effects of Salsalate

The study highlighted the importance of carefully considering the potential side effects of salsalate. Like navigating a sandstorm, caution is needed, as tinnitus and transaminitis were frequently encountered. Further research is needed to understand the underlying reasons for these adverse events and to explore alternative approaches for improving endothelial function in HIV-infected individuals.

Dr.Camel's Conclusion

This study serves as a reminder that the path to effective treatments for HIV-infected individuals remains arduous. While salsalate failed to deliver on its promise, it provides valuable insights into the challenges and complexities of this field. Further research is needed to explore alternative approaches and to ensure that new treatments are both effective and safe.

Date :
  1. Date Completed 2011-05-06
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

20613460

DOI: Digital Object Identifier

10.1097/QAD.0b013e32833c3251

Related Literature

Article Analysis
・Effects of salsalate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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