Evaluation of the protective effects of quercetin, rutin, naringenin, resveratrol and trolox against idarubicin-induced DNA damage.

Author: ArinçEmel, CelikHaydar

Paper Details 
Original Abstract of the Article :
Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of some hematological malignancies. The studies in our laboratory have clearly demonstrated that idarubicin can undergo reductive bioactivation by NADPH-cytochrome P450 reductase to free radicals with resulting form...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/20816008

データ提供:米国国立医学図書館(NLM)

Protecting Against Idarubicin-Induced DNA Damage: The Potential of Phenolic Antioxidants

This research delves into the intricate world of [cancer chemotherapy], specifically investigating the [genotoxic effects] of [idarubicin], a widely used [anthracycline anticancer drug]. The study explores the potential protective effects of various [phenolic antioxidants] against [idarubicin-induced DNA damage]. The researchers meticulously examined the ability of [quercetin, rutin, naringenin, resveratrol, and trolox] to mitigate the [DNA-damaging effects] of idarubicin, aiming to identify potential strategies for reducing the [side effects] associated with this powerful chemotherapy agent. This research provides valuable insights into the protective mechanisms of phenolic antioxidants and their potential for mitigating the genotoxic effects of chemotherapy drugs.

Phenolic Antioxidants: Potential Allies in the Fight Against Chemotherapy Side Effects

The study's findings highlight the potential of [phenolic antioxidants] as [protective agents] against [idarubicin-induced DNA damage]. The research suggests that these natural compounds may offer a promising approach for reducing the [genotoxic side effects] of chemotherapy, potentially improving the quality of life for cancer patients undergoing treatment. This study encourages further investigation into the therapeutic potential of phenolic antioxidants for mitigating the side effects of chemotherapy and enhancing the effectiveness of cancer treatment.

Navigating the Desert of Chemotherapy: Seeking Natural Solutions

This research on idarubicin-induced DNA damage reminds us that the search for effective cancer treatments often involves a delicate balance between efficacy and safety. Just as a desert traveler must carefully seek out sources of water and shelter, we must diligently seek natural solutions to mitigate the side effects of chemotherapy and improve the quality of life for cancer patients. This study encourages a holistic approach to cancer treatment, recognizing the potential of natural compounds like phenolic antioxidants for promoting well-being and mitigating the damaging effects of chemotherapy.

Dr. Camel's Conclusion

This study offers valuable insights into the protective effects of phenolic antioxidants against idarubicin-induced DNA damage, highlighting their potential for mitigating the side effects of chemotherapy and improving the quality of life for cancer patients.

Date :
  1. Date Completed 2010-12-17
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20816008

DOI: Digital Object Identifier

20816008

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English

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