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Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone.
Author: HaradaKatsuya, IrieMegumi, KayamaYukihiko, KondoYuji, MatsuokaNobuya, MiharaTakuma, NiKeni, ShoboMiwako, YamadaHiroshi
Original Abstract of the Article :
Body weight gain is one of the most serious side effects associated with clinical use of antipsychotics. However, the mechanisms by which antipsychotics induce body weight gain are unknown, and no reliable animal models of antipsychotics-induced weight gain have been established. The present studies...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.bbr.2010.08.046
データ提供:米国国立医学図書館(NLM)
Unraveling the Weight Gain Mystery: A Look at Atypical Antipsychotics
Weight gain is a common side effect of antipsychotic medications, and it can have a significant impact on individuals' health and well-being. This research investigates the mechanisms behind weight gain induced by atypical antipsychotics using animal models. The study explores the effects of olanzapine and ziprasidone, two commonly prescribed atypical antipsychotics, on weight gain and feeding behavior in rats. Their findings provide valuable insights into the potential causes of weight gain associated with these medications and suggest that olanzapine may induce weight gain by increasing food intake.
Understanding Weight Gain: A Closer Look at Olanzapine
The study reveals that olanzapine, unlike ziprasidone, leads to significant weight gain in rats, suggesting that it may play a role in weight gain associated with atypical antipsychotic medication use. This finding underscores the importance of continued research into the mechanisms behind these side effects.
Navigating the Side Effects: A Call for Caution
This research, like a trek through a desert landscape, provides a valuable insight into the complex interplay between antipsychotic medications and weight gain. The study highlights the importance of understanding the potential side effects of these medications, emphasizing the need for careful monitoring and individualized treatment plans.
Dr.Camel's Conclusion
Antipsychotic medications, like desert mirages, can sometimes have unintended consequences. This research, like a compass guiding us through the desert of medication side effects, reveals the potential link between olanzapine and weight gain, prompting us to carefully consider the risks and benefits of these medications.
Date :
- Date Completed 2011-03-22
- Date Revised 2018-12-01
Further Info :
Related Literature
English
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