Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone.

Author: HaradaKatsuya, IrieMegumi, KayamaYukihiko, KondoYuji, MatsuokaNobuya, MiharaTakuma, NiKeni, ShoboMiwako, YamadaHiroshi

Paper Details 
Original Abstract of the Article :
Body weight gain is one of the most serious side effects associated with clinical use of antipsychotics. However, the mechanisms by which antipsychotics induce body weight gain are unknown, and no reliable animal models of antipsychotics-induced weight gain have been established. The present studies...See full text at original site
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引用元:
https://doi.org/10.1016/j.bbr.2010.08.046

データ提供:米国国立医学図書館(NLM)

Unraveling the Weight Gain Mystery: A Look at Atypical Antipsychotics

Weight gain is a common side effect of antipsychotic medications, and it can have a significant impact on individuals' health and well-being. This research investigates the mechanisms behind weight gain induced by atypical antipsychotics using animal models. The study explores the effects of olanzapine and ziprasidone, two commonly prescribed atypical antipsychotics, on weight gain and feeding behavior in rats. Their findings provide valuable insights into the potential causes of weight gain associated with these medications and suggest that olanzapine may induce weight gain by increasing food intake.

Understanding Weight Gain: A Closer Look at Olanzapine

The study reveals that olanzapine, unlike ziprasidone, leads to significant weight gain in rats, suggesting that it may play a role in weight gain associated with atypical antipsychotic medication use. This finding underscores the importance of continued research into the mechanisms behind these side effects.

Navigating the Side Effects: A Call for Caution

This research, like a trek through a desert landscape, provides a valuable insight into the complex interplay between antipsychotic medications and weight gain. The study highlights the importance of understanding the potential side effects of these medications, emphasizing the need for careful monitoring and individualized treatment plans.

Dr.Camel's Conclusion

Antipsychotic medications, like desert mirages, can sometimes have unintended consequences. This research, like a compass guiding us through the desert of medication side effects, reveals the potential link between olanzapine and weight gain, prompting us to carefully consider the risks and benefits of these medications.

Date :
  1. Date Completed 2011-03-22
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20816897

DOI: Digital Object Identifier

10.1016/j.bbr.2010.08.046

SNS
PICO Info
in preparation
Languages

English

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