ACE inhibitors for the treatment of hypertension drug selection by means of the SOJA method.

Author: EdgarLesley, HoggAnita, JanknegtRobert, MairsJill, Mc ElnayJames, ScottMike, TimoneyMark

Paper Details 
Original Abstract of the Article :
ACE inhibitors have proven to be effective blood pressure lowering agents with an excellent tolerability profile. The family of these drugs is still expanding, necessitating the definition of selection criteria in order to choose the "right drug". In this article the ACE inhibitors available in the ...See full text at original site
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引用元:
https://doi.org/10.2174/157488711793980156

データ提供:米国国立医学図書館(NLM)

ACE Inhibitors for Hypertension: Choosing the Right Drug

The field of [hypertension treatment] is constantly evolving. This study dives into the complex world of ACE inhibitors, a family of drugs known for their effectiveness in lowering blood pressure. The researchers used a method called SOJA, which analyzes drug selection criteria and assigns weights based on their importance. They evaluated various ACE inhibitors available in the United Kingdom, considering factors like formulation, indications, bioavailability, and side effects.

Interestingly, ramipril emerged as the top performer, followed by perindopril, lisinopril, and enalapril. The researchers highlight the impact of well-documented effects on clinical endpoints like cardiovascular morbidity and mortality, which contributed significantly to ramipril's high score.

ACE Inhibitors and Cardiovascular Health

The study's findings suggest that ramipril stands out as a potential frontrunner among ACE inhibitors, particularly due to its favorable impact on cardiovascular health. This underscores the importance of considering a drug's overall profile, including its effects on clinically relevant outcomes, when making treatment decisions.

Navigating the World of ACE Inhibitors

This research provides valuable insights for healthcare professionals and patients navigating the world of ACE inhibitors. It emphasizes the importance of a comprehensive approach to drug selection, considering various factors beyond just efficacy. For patients, it may encourage a conversation with their healthcare provider to discuss the specific benefits and risks of different ACE inhibitors, considering their individual health needs and goals.

Dr.Camel's Conclusion

This study, much like a camel traversing a vast desert, navigates the complex landscape of ACE inhibitors. It highlights the importance of understanding a drug's comprehensive profile, not just its immediate impact on blood pressure. Remember, everyone is different, just like each camel has its own unique stride, and the right ACE inhibitor for one person might not be the right one for another. Consulting your healthcare provider is crucial for making informed decisions about your health.

Date :
  1. Date Completed 2011-05-17
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

20868351

DOI: Digital Object Identifier

10.2174/157488711793980156

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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