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Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial.

Author: , AlexanderRichard B, AndersonRodney U, CenLiyi, ChuaiShannon, KriegerJohn N, KusekJohn W, LandisJ Richard, LitwinMark S, McNaughton-CollinsMary, NickelJ Curtis, NybergLeroy M, O'LearyMichael, PontariMichel A, PropertKathleen J, SchaefferAnthony J, ShoskesDaniel A, WhitePaige C, ZeitlinScott

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Pregabalin, a medication effective for other chronic pain syndromes, was not superior to placebo in treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) symptoms in a randomized, double-blind, placebo-controlled trial of 324 men. While pregabalin was associated with improvements in symptom scores and a higher Global Response Assessment response rate, the primary outcome of a 6-point decrease in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score was not met.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Evidence suggests that the urogenital pain of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) may be neuropathic. METHODS: This randomized, double-blind, placebo-controlled trial was conducted across 10 tertiary care centers in North America to determine whether pregabalin, w...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20876412

データ提供：米国国立医学図書館（NLM）

Pregabalin for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Journey through the Desert of Pain

Greetings from Dr. Camel, your guide through the vast and often challenging desert of chronic pain. This randomized, double-blind, placebo-controlled trial investigates the effectiveness of pregabalin, a medication commonly used to treat neuropathic pain, for men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The researchers aim to determine if pregabalin can provide relief from the debilitating pain associated with this condition. Their findings offer valuable insights into the potential role of pregabalin in managing this difficult-to-treat condition.

Pregabalin's Potential: A Beacon of Hope in the Desert of Pain

While pregabalin did not outperform placebo in the primary outcome of a 6-point decrease in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score, it did show significant reductions in NIH-CPSI total score and subscores, as well as a higher Global Response Assessment response rate. These findings suggest that pregabalin may offer some benefit for men with CP/CPPS, particularly in reducing pain and improving overall symptom severity. It's like finding a beacon of hope in the vast and often desolate desert of chronic pain.

Navigating the Desert of Chronic Pain: Understanding the Complexities

The study highlights the complexities of managing chronic pain. While pregabalin may offer some relief for CP/CPPS, it's crucial to remember that individual responses can vary. Further research is needed to fully understand the mechanisms of action and the long-term effects of pregabalin in this population. Just like navigating a desert landscape, managing chronic pain requires a personalized approach that takes into account the individual's unique circumstances and needs.

Dr. Camel's Conclusion

The desert of chronic pain can be a daunting and unforgiving landscape. This study sheds light on the potential role of pregabalin in managing CP/CPPS, offering a glimmer of hope for those suffering from this debilitating condition. However, it's essential to approach treatment with a personalized and nuanced perspective, recognizing the complexities of chronic pain and the importance of continued research.

Date :
  1. Date Completed 2010-10-28
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

20876412

DOI: Digital Object Identifier

NIHMS507892

Related Literature

Article Analysis
・Effective treatment of pelvic pain
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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