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Biphasic dosing regimen of meclizine for prevention of postoperative nausea and vomiting in a high-risk population.

Author: BoppEric J, DanielCarole, EstradaT Jose L, KildayJeremy M, PellegriniJoseph E, SpradlingJames C

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored the effectiveness of meclizine in preventing postoperative nausea and vomiting (PONV) in high-risk patients. Meclizine administered the night before and the day of surgery was effective in reducing nausea and vomiting compared to placebo.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to determine if giving 50 mg of meclizine the night before and on the day of surgery would effectively reduce postoperative nausea and vomiting (PONV) for the entire 24 hours after surgery in patients identified as being at high risk for PONV Subjects were randomly assi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20977130

データ提供：米国国立医学図書館（NLM）

Biphasic Meclizine Dosing: A Potential Solution for Postoperative Nausea and Vomiting

The [prevention of postoperative nausea and vomiting (PONV)] is a crucial aspect of perioperative care, as PONV can significantly impact patient comfort and recovery. This study explores the effectiveness of a biphasic dosing regimen of meclizine for preventing PONV in patients considered high-risk for this complication.

A Novel Approach to PONV Prevention

The study found that administering 50 mg of meclizine the night before and on the day of surgery effectively reduced PONV in high-risk patients compared to placebo, even when accounting for intravenous ondansetron administration. This biphasic dosing strategy offers a potential advantage in preventing PONV for a prolonged period after surgery, potentially improving patient comfort and facilitating a smoother recovery.

Optimizing Antiemetic Strategies

This research underscores the importance of implementing comprehensive antiemetic strategies to minimize the incidence and severity of PONV. The biphasic meclizine dosing regimen, coupled with other antiemetic medications, may offer a more effective approach to managing this common postoperative complication.

Dr.Camel's Conclusion

Just as a camel relies on its ability to store water to survive long desert journeys, this research explores a novel approach to preventing PONV, a common postoperative challenge. The study suggests that a biphasic meclizine dosing regimen could provide a more effective and sustained protection against PONV, enhancing patient comfort and facilitating a smoother recovery after surgery.
Date :
  1. Date Completed 2010-12-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20977130

DOI: Digital Object Identifier

20977130

Related Literature

Article Analysis
・Side Effects of meclizine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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