N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects.

Author: AgostonGregory E, CaoJianjing, KatzJonathan L, KopajticTheresa A, LiSu-Min, NewmanAmy Hauck, O'CallaghanMatthew J

Paper Details 
Original Abstract of the Article :
Previous studies suggested that differences between the behavioral effects of cocaine and analogs of benztropine were related to the relatively slow onset of action of the latter compounds. Several N-substituted benztropine analogs with a relatively fast onset of effects were studied to assess wheth...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033723/

データ提供:米国国立医学図書館(NLM)

The Quest for Cocaine-Like Effects: A Tale of Benztropine Analogs

In the realm of [pharmacology], scientists are constantly searching for new drugs to treat a variety of conditions. This research delves into the fascinating world of [dopamine transporter ligands] and their potential for treating [cocaine addiction]. The study focuses on the critical question of whether the speed at which a drug takes effect influences its addictive properties. Researchers used a variety of [N-substituted benztropine analogs] to understand how quickly they act on the [dopamine transporter] and compared their effects to those of cocaine. Their findings provide valuable insights into the complex interplay between [drug efficacy], [onset of action], and [addiction potential].

Fast Onset Doesn't Always Mean Cocaine-Like Effects

The results of this study revealed that a rapid onset of action did not automatically equate to cocaine-like effects. This suggests that other factors beyond the speed of action are also crucial for determining the addictive potential of a drug. This is a significant finding that may challenge conventional wisdom in the field of [drug development].

Navigating the Complex Terrain of Drug Interactions

This research underscores the importance of understanding the various mechanisms by which drugs interact with the brain and body. It highlights the need to go beyond simply measuring the speed of action and to consider the broader range of factors that contribute to the [pharmacological profile] of a drug. It's like navigating a vast desert – you need to consider not only how quickly you can traverse it, but also the potential obstacles and hazards along the way.

Dr.Camel's Conclusion

This research adds another layer of complexity to the study of [dopamine transporter ligands] and their potential for treating [cocaine addiction]. The authors have demonstrated that a fast onset of action alone is not a determining factor in a drug's addiction potential. This discovery has important implications for future drug development and highlights the need for a comprehensive understanding of the complex interactions between drugs and the brain.

Date :
  1. Date Completed 2011-03-03
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21088247

DOI: Digital Object Identifier

PMC3033723

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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