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Antidepressants, metabolites, and apparent drug resistance.

Author: ManjiH K, PotterW Z

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Antidepressant metabolites can have different properties than the parent drug, leading to drug resistance or intolerance. This article explores the pharmacodynamic consequences of metabolism and highlights the potential role of active metabolites in drug response.
Paper Details　
Original Abstract of the Article :
Antidepressant drugs are extensively metabolized prior to elimination from the body. These metabolites usually have biological and chemical properties different from those of the parent drug. This article explores the pharmacodynamic consequences of such metabolism as possibly contributing to failur...See full text at original site
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引用元：
https://doi.org/10.1097/00002826-199001001-00005

データ提供：米国国立医学図書館（NLM）

The Complexities of Antidepressant Metabolism and Drug Resistance

This study explores the potential role of antidepressant metabolism in drug resistance and tolerance. The study utilizes a [methodology used] to investigate the [primary aim] of this study. The authors discovered [key findings], suggesting that the metabolites of certain antidepressants can have different pharmacological effects than their parent drugs, potentially influencing treatment outcomes.

Understanding the Challenges of Antidepressant Treatment

This study sheds light on the complex interplay between antidepressant metabolism and treatment response, highlighting the potential for individual variations in drug metabolism to affect treatment outcomes. The findings emphasize the importance of considering metabolic factors when prescribing antidepressants, particularly in cases of drug resistance or intolerance.

Navigating the Desert of Mental Health Treatment

This research underscores the importance of personalized medicine in mental health treatment, tailoring therapy to individual patient needs and considering factors like drug metabolism. It's like navigating the vast and diverse landscape of mental health treatment, where understanding the unique characteristics of each patient is essential for finding the most effective path to recovery.

Dr. Camel's Conclusion

As a researcher who has witnessed the challenges of mental health treatment, I find this study to be a valuable reminder of the complexities involved in finding effective therapies. The findings emphasize the importance of a multidisciplinary approach to treatment, considering factors such as drug metabolism and individual patient characteristics. This research underscores the ongoing need for innovation and personalized care in the field of mental health.

Date :
  1. Date Completed 1990-09-07
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

2116227

DOI: Digital Object Identifier

10.1097/00002826-199001001-00005

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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