Paper Details 
Original Abstract of the Article :
Due to escalating antimicrobial resistance amongst Gram-negative organisms, the choice of effective empirical antimicrobial regimens has become challenging. Monte Carlo simulations were conducted for conventional and prolonged infusion regimens of doripenem, imipenem and meropenem using pharmacokine...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.ijantimicag.2010.10.024

データ提供:米国国立医学図書館(NLM)

Fighting Antimicrobial Resistance: A Global Battle in the Desert of Infections

The global threat of antimicrobial resistance is a growing concern, like a creeping desert encroaching on fertile lands. Effective empirical antimicrobial regimens are crucial for combating infections, particularly those caused by Gram-negative bacteria. This study, like a strategic expedition across a diverse desert, explores the pharmacodynamic profiles of intravenous antibiotics against prevalent Gram-negative organisms across the globe.

Optimizing Antibiotic Therapy: A Quest for Effective Dosing

The researchers, like skilled desert strategists, conducted Monte Carlo simulations using pharmacokinetic data from patients and minimum inhibitory concentration data from various regions of the world. They aimed to determine the optimal dosing regimens for carbapenem antibiotics, a class of drugs commonly used to treat severe infections.

A Global Perspective: Combating Resistance in Diverse Regions

This research, like a global map of the desert landscape, provides a comprehensive view of the challenges posed by antimicrobial resistance in different regions. The study's findings highlight the need for region-specific dosing guidelines and the importance of ongoing surveillance to monitor resistance trends and optimize antibiotic treatment strategies.

Dr. Camel's Conclusion

This study underscores the critical need for a global strategy to combat antimicrobial resistance. By analyzing the pharmacodynamic profiles of antibiotics and identifying region-specific resistance patterns, the researchers offer valuable insights for optimizing antibiotic therapy and improving patient outcomes.

Date :
  1. Date Completed 2011-08-30
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21168997

DOI: Digital Object Identifier

10.1016/j.ijantimicag.2010.10.024

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.