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Effect of fenbendazole on three behavioral tests in male C57BL/6N mice.

Author: BraytonCory F, DaherJoão P L, DawsonTed M, GadadBharathi S, HutchinsonEric K, PletnikovMikhail V, WatsonJulie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examines the effects of fenbendazole, a common treatment for pinworms in laboratory rodents, on the behavior of mice. The findings suggest that while fenbendazole treatment does not significantly affect open field or elevated plus maze testing, it may negatively impact motor ability, as observed in rotarod tests. The study recommends caution when interpreting behavioral data from mice treated with fenbendazole.
Paper Details　
Original Abstract of the Article :
Pinworms are highly contagious parasites of laboratory rodents that often are treated with fenbendazole. To our knowledge, the effect of fenbendazole at therapeutic dosages on behavioral tests in mice has not been evaluated. Here we studied 6-wk-old male C57BL/6N mice. We compared the behavior of co...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994049/

データ提供：米国国立医学図書館（NLM）

Fenbendazole: A Potential Roadblock in Behavioral Studies

The study of rodent behavior is a journey through the intricate pathways of their brains, seeking to understand the impact of various factors on their actions. This research explores the potential effects of fenbendazole, a commonly used anti-parasitic medication, on the behavior of male C57BL/6N mice. The researchers investigate the impact of fenbendazole treatment on three behavioral tests: open field, elevated plus maze, and rotarod. They aim to uncover any potential interference of fenbendazole with these tests, ensuring the reliability of behavioral research in the presence of this medication.

Fenbendazole: A Potential Impact on Motor Ability Tests

The study suggests that fenbendazole treatment may affect motor ability tests, such as the rotarod test. However, it appears to have minimal impact on tests assessing central, peripheral, and vertical activity in the open field and anxiety levels in the elevated plus maze.

Navigating the Desert of Behavioral Research

This study provides valuable insights for navigating the desert of behavioral research, highlighting the potential impact of fenbendazole on motor ability tests. It underscores the importance of carefully considering the potential influence of medications on animal behavior, especially in the context of research involving rodents.

Dr.Camel's Conclusion

Fenbendazole, though effective for treating parasites, might be a potential roadblock in behavioral research, particularly when assessing motor ability. Navigating the desert of behavioral research requires careful consideration of these factors to ensure the reliability and accuracy of study results. Remember, every journey through this desert requires a keen eye for detail.

Date :
  1. Date Completed 2011-08-03
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21205447

DOI: Digital Object Identifier

PMC2994049

Related Literature

Article Analysis
・Effective treatment of pinworms
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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