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A multi-center, open-label study to evaluate the safety and efficacy of a sequential treatment regimen of clobetasol propionate 0.05% spray followed by Calcitriol 3 mg/g ointment in the management of plaque psoriasis.

Author: BrodellRobert T, BruceSuzanne, ColónLuz E, GottschalkRonald W, HudsonCharles P, JohnsonLori A, WeissJonathan S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Clobetasol propionate is a commonly used corticosteroid for moderate-to-severe psoriasis, but its potential side effects limit long-term use. Topical vitamin D is a safer option for mild-to-moderate psoriasis. This study explored the use of clobetasol propionate with calcitriol to manage moderate-to-severe psoriasis over time.
Paper Details　
Original Abstract of the Article :
Psoriasis is a hyperproliferative and inflammatory skin disorder that affects roughly 2 percent of the worldwide population. Clobetasol propionate is the most common corticosteroid used to treat moderate-to-severe psoriasis but the potential for side effects limits its long-term use. Topical vitamin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/21283920

データ提供：米国国立医学図書館（NLM）

A Multi-Center, Open-Label Study to Evaluate the Safety and Efficacy of a Sequential Treatment Regimen of Clobetasol Propionate 0.05% Spray Followed by Calcitriol 3 mg/g Ointment in the Management of Plaque Psoriasis

Psoriasis, a chronic skin condition, can be a persistent desert of discomfort. This study, like a caravan searching for a cure, investigates the effectiveness of a sequential treatment regimen for plaque psoriasis. The researchers evaluated the combined use of clobetasol propionate, a potent topical steroid, and calcitriol, a vitamin D analog, in managing this challenging skin condition.

The study, with its multi-center design, aims to provide a comprehensive assessment of this treatment approach. The researchers sought to determine the safety and efficacy of this regimen, hoping to find a long-term solution for patients with psoriasis. While the study acknowledges the need for further research, it suggests that this combination therapy could offer a promising approach to managing plaque psoriasis.

Exploring New Treatment Options for Psoriasis

This study highlights the ongoing search for effective and safe treatments for psoriasis. The researchers' investigation into a sequential regimen of clobetasol propionate and calcitriol offers a potential new avenue for managing this chronic skin condition.

Improving Patient Outcomes and Quality of Life

This study's findings could lead to improved treatment options for patients with psoriasis. By combining different therapies, healthcare providers can potentially achieve better control of the condition, minimizing the impact on patients' lives.

Dr. Camel's Conclusion

Psoriasis, like a persistent desert sandstorm, can wreak havoc on the skin. This study sheds light on a potential new treatment strategy for managing this chronic condition. The investigation into a sequential regimen of clobetasol propionate and calcitriol offers hope for more effective and long-lasting solutions for patients with psoriasis, potentially leading to improved quality of life.

Date :
  1. Date Completed 2011-08-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21283920

DOI: Digital Object Identifier

21283920

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Article Analysis
・Side Effects of calcitriol topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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