Paper Details

  1. Home
  2. Paper Details

In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons.

Author: KombianS B, PhillipsO A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oxazolidinones, a new class of antibacterial agents, were examined for their neuroactivity in vitro. Oxazolidinones containing both morpholine and triazole functional groups showed neuroactivity, while those containing morpholine and acetamide or piperazine and triazolyl functional groups had minimal acute neuroactivity.
Paper Details　
Original Abstract of the Article :
Oxazolidinones are a novel class of antibacterial agents with demonstrated activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and enterococci. Prolonged clinical use of linezolid, the prototypical oxazolidinone, results in peripheral, central and opt...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.neuroscience.2011.01.062

データ提供：米国国立医学図書館（NLM）

Oxazolidinones: Navigating the Neurological Landscape of Antibacterial Therapy

Oxazolidinones are a class of antibiotics effective against resistant bacteria. However, prolonged use of linezolid, the prototypical oxazolidinone, can lead to neurological side effects. This study investigates the potential neurotoxicity of linezolid and other oxazolidinones in vitro.

Potential for Safer Alternatives

The study found that some oxazolidinones, particularly those containing both morpholine and triazole functional groups, had neuroactive effects in vitro. However, other oxazolidinones, such as linezolid, had minimal neuroactivity. These findings suggest that some oxazolidinones may be safer than others, offering a potential advantage for treating bacterial infections without significant neurological risks.

Balancing Antimicrobial Power and Neurological Safety

This research highlights the importance of considering the potential neurological effects of antibacterial drugs. It underscores the need to develop safer alternatives that are effective against resistant bacteria without causing significant neurological side effects. As we explore new approaches to combatting bacterial infections, we must navigate the delicate balance between antimicrobial efficacy and neurological safety.

Dr.Camel's Conclusion

In the vast desert of antimicrobial research, we must seek safe and effective solutions. This study offers a valuable insight into the neurological effects of oxazolidinones. By understanding the potential risks and benefits of various antibiotics, we can choose the best path for treating bacterial infections while minimizing the risk of neurological side effects.
Date :
  1. Date Completed 2011-08-04
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21296129

DOI: Digital Object Identifier

10.1016/j.neuroscience.2011.01.062

Related Literature

Article Analysis
・Effects of linezolid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.