[Effects of bortezomib combined with daunorubicin on proliferation and apoptosis in primary adult acute leukemia].

Author: GongYu-ping, YangXi, ZhengBo-hui, ZhouRui-qing

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To assess effects of proteasome inhibitor Bortezomib (Bor) in combination with Daunorubicin (DNR) on proliferation, apoptosis and the expression of Bcl-2 mRNA in primary leukemia cells in vitro. METHODS: Primary leukemia cells were isolated from bone marrow of adult acute leukemia patien...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/21302442

データ提供:米国国立医学図書館(NLM)

Bortezomib and Daunorubicin: A Powerful Combination Against Acute Leukemia

Acute leukemia is a serious blood cancer that requires aggressive treatment. This study investigates the combined effects of bortezomib (Bor), a proteasome inhibitor, and daunorubicin (DNR), a chemotherapy drug, on primary leukemia cells.

The researchers found that combining Bor and DNR resulted in a synergistic effect, enhancing the anti-leukemia activity of both drugs. The combination significantly increased apoptosis (programmed cell death) in leukemia cells and reduced the expression of Bcl-2, a protein that inhibits apoptosis. These findings suggest that combining Bor and DNR could be a more effective treatment for acute leukemia than either drug alone.

A Synergistic Approach to Treating Acute Leukemia: The Power of Combination Therapy

This study highlights the potential of combining different drugs to enhance their anti-cancer effects. The synergistic effect observed with Bor and DNR suggests that this combination therapy could be a more effective and targeted approach for treating acute leukemia.

Navigating the Desert of Leukemia Treatment: Finding Effective Therapies

This study sheds light on the complex landscape of leukemia treatment and the importance of finding innovative approaches to combat this challenging disease. It's like discovering a new weapon in the fight against cancer, offering hope for a more effective and targeted approach.

Dr.Camel's Conclusion

The desert of leukemia treatment is vast and unforgiving, but this study offers hope by demonstrating the power of combination therapy. Combining Bor and DNR could be like harnessing the forces of nature to create a powerful storm against cancer, offering a more effective and targeted approach to combat this devastating disease.

Date :
  1. Date Completed 2011-09-29
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21302442

DOI: Digital Object Identifier

21302442

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PICO Info
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Languages

Chinese

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