Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.

Author: AmstutzUrsula, CarletonBruce C, HaydenMichael R, RossColin J, SistonenJohanna, VisscherHenk

Paper Details 
Original Abstract of the Article :
Individual response to medication is highly variable. For many drugs, a substantial proportion of patients show suboptimal response at standard doses, whereas others experience adverse drug reactions (ADRs). Pharmacogenomics aims to identify genetic factors underlying this variability in drug respon...See full text at original site
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引用元:
https://doi.org/10.1097/FJC.0b013e3182163b82

データ提供:米国国立医学図書館(NLM)

Pharmacogenomics: Tailoring Medicine to Each Patient

In the vast landscape of medicine, we strive to find the perfect treatment for every patient. However, like navigating a desert, finding the right path can be tricky. Each person's body reacts differently to drugs, making it crucial to personalize treatments. This research focuses on pharmacogenomics, a field that explores how our genes influence drug responses. The goal is to identify genetic factors that explain why some individuals experience suboptimal effects or adverse drug reactions (ADRs) from medications. By understanding these individual differences, we can develop more effective and safer therapies. This research delves into the pharmacogenomics of cardiovascular drugs and ADRs, including warfarin, clopidogrel, β-blockers, and more. The authors emphasize the need for specific studies on pediatric patients, as developmental changes can impact drug response. The study highlights the importance of tailoring medication to each patient's unique genetic makeup, much like customizing a camel's saddle to fit its back perfectly.

Individualized Medicine is Key

This research suggests that personalized medicine based on an individual's genetic makeup is essential for optimizing drug effectiveness and minimizing risks. It demonstrates that genes play a crucial role in drug response, especially for cardiovascular medications. The study highlights the need for more research, particularly in the pediatric population, to further refine our understanding of these genetic influences.

Optimizing Drug Response: A Journey Through the Body

It's like a camel traversing the desert, each step must be planned to conserve energy and avoid hazards. Our bodies are complex systems, and drugs are like the supplies we carry along the way. We need to carefully choose the right drugs, the right doses, and understand how our unique biological journey impacts the way we respond to them. This research helps us navigate that journey with greater precision, ensuring a smoother and more effective experience.

Dr.Camel's Conclusion

This research illuminates the immense potential of pharmacogenomics in personalizing medicine for cardiovascular treatments. It emphasizes the need for further research, particularly in pediatric populations, to optimize drug response and ensure safe and effective treatments for all individuals.

Date :
  1. Date Completed 2012-04-03
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

21386709

DOI: Digital Object Identifier

10.1097/FJC.0b013e3182163b82

Related Literature

SNS
PICO Info
in preparation
Languages

English

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