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[A case of castration-refractory prostate cancer showing marked decrease of serum PSA level after zoledronic acid treatment with estramustine phosphate and prednisolone].

Author: AoyamaMasato, HirayamaYukiyoshi, ItoYoshihiro, KanamaruTomohiro, KawamuraMasaki, NakamuraNorihiro, SonodaTeppei

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a 66-year-old man with metastatic castration-resistant prostate cancer (CRPC) who showed a remarkable response to zoledronic acid treatment. The PSA level decreased dramatically, and MRI imaging revealed a reduction in bone metastases. This suggests that zoledronic acid may have potential antitumor effects in addition to its known efficacy in preventing skeletal-related events in CRPC patients.
Paper Details　
Original Abstract of the Article :
A 66-year-old man was referred to our outpatient clinic for an elevated serum prostatic-specific antigen (PSA 4,319 ng/ mL). Magnetic resonance imaging (MRI) showed multiple metastatic lesions in the bones. The patient had received androgen deprivation therapy, but six months after treatment, he was...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/21403461

データ提供：米国国立医学図書館（NLM）

Zoledronic Acid: A Potential Treatment for Castration-Refractory Prostate Cancer

In the realm of oncology, the search for effective treatments for prostate cancer, particularly in its most aggressive forms, is an ongoing quest. This case report describes a patient with castration-refractory prostate cancer (CRPC) who experienced a remarkable decrease in serum PSA levels after treatment with zoledronic acid, in combination with estramustine phosphate and prednisolone. This finding highlights the potential of zoledronic acid as a therapeutic agent for CRPC, even in cases resistant to conventional hormone therapies.

Zoledronic Acid's Potential as an Anti-tumor Agent

This case report, much like a single grain of sand in the vast desert, presents a compelling anecdote suggesting the potential of zoledronic acid in treating CRPC. The dramatic decrease in PSA levels, coupled with the observed reduction in bone metastases, suggests that zoledronic acid may possess an anti-tumor effect beyond its known ability to prevent skeletal-related events. Further research is needed to confirm this promising observation and to determine the optimal dosage and treatment regimens for zoledronic acid in CRPC.

Implications for Prostate Cancer Treatment

This research, like a refreshing spring in the desert, offers hope for patients with CRPC. Zoledronic acid, once primarily known for its bone-protective properties, may hold the key to effectively treating this challenging form of cancer. While further research is needed to solidify its role in CRPC therapy, this case report provides a compelling starting point for exploring its potential benefits.

Dr.Camel's Conclusion

Zoledronic acid, much like a resilient camel traversing the harsh desert, emerges as a potential therapeutic weapon against CRPC. This case report provides a glimmer of hope in the ongoing battle against this aggressive form of cancer.
Date :
  1. Date Completed 2011-04-21
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21403461

DOI: Digital Object Identifier

21403461

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Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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