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Hematologic side effects of azathioprine and mycophenolate in kidney transplantation.

Author: HabasE, KhammajA, RayaniA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Mycophenolate and azathioprine hematologic adverse effects are not significantly different as long as close observation and follow-up are performed. Therefore, mycophenolate- and azathioprine-based maintenance regimens can be used interchangeably without significant hematologic adverse effects. White blood cells increased significantly after the transplantation during the mycophenolate period (9.2×10(3), P=.001, .017).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Immunosuppressive therapy post-kidney transplantation is usually used continuously and should be regularly monitored. Inadequate dosages of immunosuppressive drugs and lack of regular monitoring can lead to either severe side effects or allograft rejection. AIM: To study the hematologic...See full text at original site
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引用元：
https://doi.org/10.1016/j.transproceed.2011.01.077

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Immunosuppression: Balancing the Scales of Rejection and Side Effects

Kidney transplantation, a delicate balancing act between preventing rejection and minimizing side effects, can be a challenging journey, like navigating a vast and unforgiving desert. This study investigates the hematologic side effects of two commonly used immunosuppressant drugs, azathioprine and mycophenolate, in kidney transplant recipients. The researchers monitored the blood counts of 59 patients who received both drugs and found that both medications had similar hematologic effects, with no significant differences in overall blood cell counts. However, they observed that azathioprine was associated with increased red blood cell size and iron levels, while mycophenolate was associated with increased white blood cell counts. The study highlights the importance of careful monitoring and individualized adjustments to ensure optimal outcomes for kidney transplant recipients.

A Personalized Compass: Tailoring Immunosuppression to Individual Needs

This study underscores the importance of personalized medicine in managing immunosuppression after kidney transplantation. The researchers found that while both azathioprine and mycophenolate have similar hematologic effects, individual patients may experience different side effects. This highlights the need for careful monitoring and individualized adjustments to ensure optimal outcomes and minimize side effects.

Balancing the Scales of Immunosuppression: A Guide Through the Desert

This study offers valuable insights into the hematologic side effects of two commonly used immunosuppressant drugs, azathioprine and mycophenolate, in kidney transplant recipients. By understanding the potential side effects of these medications and developing strategies for managing them, healthcare providers can better navigate the desert of immunosuppression, ensuring optimal outcomes and minimizing side effects for patients.

Dr.Camel's Conclusion

This study compares the hematologic side effects of azathioprine and mycophenolate in kidney transplant recipients, highlighting the importance of individualized monitoring and adjustments to optimize outcomes and minimize side effects. The research underscores the need for a personalized approach to managing immunosuppression in this complex patient population.
Date :
  1. Date Completed 2011-07-22
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

21440745

DOI: Digital Object Identifier

10.1016/j.transproceed.2011.01.077

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・Side Effects of azathioprine
SNS
PICO Info
in preparation
Languages

English

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