An injectable calcium phosphate cement for the local delivery of paclitaxel to bone.

Author: JansenJohn A, KamphuisG J Bernard, Lopez-HerediaMarco A, ThünePeter C, WalboomersX Frank, ÖnerF Cumhur

Paper Details 
Original Abstract of the Article :
Bone metastases are usually treated by surgical removal, fixation and chemotherapeutic treatment. Bone cement is used to fill the resection voids. The aim of this study was to develop a local drug delivery system using a calcium phosphate cement (CPC) as carrier for chemotherapeutic agents. CPC cons...See full text at original site
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引用元:
https://doi.org/10.1016/j.biomaterials.2011.04.010

データ提供:米国国立医学図書館(NLM)

Calcium Phosphate Cement: A Novel Drug Delivery System for Local Paclitaxel Administration to Bone

Bone metastases, a common complication of cancer, often require [surgical intervention] and [chemotherapy]. This study explores the potential of [calcium phosphate cement (CPC)] as a local drug delivery system for [paclitaxel], a chemotherapy drug. The researchers developed a [CPC formulation] that effectively [loaded and released] paclitaxel, demonstrating its potential for localized drug delivery to bone. The study's findings suggest that [CPC] can serve as a biocompatible and biodegradable carrier for [chemotherapeutic agents], enabling targeted drug delivery to the site of bone metastases. A key highlight of the study is the demonstration that [paclitaxel released from CPC] retained its [anti-cancer activity], highlighting the potential for improved efficacy and reduced systemic side effects.

Targeting Bone Metastases: A New Approach to Paclitaxel Delivery

The results of this research offer a promising new approach to [bone metastasis treatment]. The study's findings suggest that [CPC] can be used as a carrier for [paclitaxel], enabling localized drug delivery and potentially reducing systemic side effects associated with conventional chemotherapy.

A New Frontier in Bone Cancer Treatment: Localized Drug Delivery Systems

This study represents a significant advancement in the field of [bone cancer treatment]. The development of [localized drug delivery systems] such as [CPC] has the potential to revolutionize the treatment of bone metastases, improving efficacy and minimizing systemic toxicity. Further research is needed to optimize the use of CPC and explore its potential for other cancer types.

Dr. Camel's Conclusion

Just as a camel can store water in its hump to navigate the arid desert, this innovative drug delivery system utilizes calcium phosphate cement to deliver paclitaxel directly to the site of bone metastases. This targeted approach holds promise for improved treatment outcomes and reduced side effects. By embracing cutting-edge technologies and fostering collaborative research, we can continue to advance our understanding and treatment of cancer.

Date :
  1. Date Completed 2011-09-19
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21529931

DOI: Digital Object Identifier

10.1016/j.biomaterials.2011.04.010

Related Literature

SNS
PICO Info
in preparation
Languages

English

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