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Cytotoxic T lymphocyte antigen 4 immunoglobulin modified dendritic cells attenuate allergic airway inflammation and hyperresponsiveness by regulating the development of T helper type 1 (Th1)/Th2 and Th2/regulatory T cell subsets in a murine model of asthma.

Author: ChenY, FuZ, LiuE, LuoJ, WangL, YingL, ZhouC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the therapeutic effects of adoptive transfer of DC-CTLA4Ig, gene-modified dendritic cells, into mice with experimental asthma. The study found that DC-CTLA4Ig reduced airway hyperresponsiveness, relieved asthmatic airway inflammation, and altered the balance of Th1/Th2 cytokine production in the lungs.
Paper Details　
Original Abstract of the Article :
T helper type 2 (Th2) and regulatory T cells (T(reg) ) have been postulated to have critical roles in the pathogenesis of allergic asthma. Cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) gene-modified dendritic cells (DC-CTLA4Ig) have the potential to reduce Th2 cells and induce T(reg) cel...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110329/

データ提供：米国国立医学図書館（NLM）

Asthma: Finding Balance in the Desert of Inflammation

Asthma is a chronic inflammatory disease of the airways, characterized by wheezing, coughing, and shortness of breath. This research explores the potential of cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) gene-modified dendritic cells (DC-CTLA4Ig) to modulate the immune response in asthma. The study investigates the therapeutic effects of DC-CTLA4Ig in a murine model of asthma, examining its ability to reduce airway inflammation and hyperresponsiveness.

A New Oasis for Asthma: Modulating the Immune Response

The study reveals that DC-CTLA4Ig treatment effectively reduces airway hyperresponsiveness, alleviates airway inflammation, and alters the balance of T helper cell subsets in the lungs. This suggests that DC-CTLA4Ig could be a promising new therapeutic approach for asthma, offering a way to modulate the immune system and restore balance in the airways. It's like finding a hidden oasis in the desert of asthma, where the immune system is gently guided back to a state of equilibrium.

Hope for Asthma Patients: Finding Balance in the Desert

This research provides a beacon of hope for patients suffering from asthma. It's like discovering a new oasis in the desert of inflammation, offering a potential path to better control and management of the disease. The study underscores the importance of exploring innovative approaches to modulate the immune response and to develop targeted therapies that address the underlying causes of asthma.

Dr. Camel's Conclusion

This research provides a compelling case for the therapeutic potential of DC-CTLA4Ig in the treatment of asthma. It's like finding a new oasis in the vast desert of asthma research, offering a glimmer of hope for patients seeking more effective treatments. The study inspires further exploration of the role of immune modulation in managing asthma and the development of personalized therapies that cater to individual needs.

Date :
  1. Date Completed 2011-08-29
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21545583

DOI: Digital Object Identifier

PMC3110329

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English

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