Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia.

Author: AkdimFatima, BakerBrenda F, FlaimJoAnn D, FuhrRainard, GearyRichard S, KasteleinJohn J P, SuJohn, TribbleDiane L, WedelMark K, YuRosie

Paper Details 
Original Abstract of the Article :
Mipomersen, an apolipoprotein (apo) B synthesis inhibitor, has been shown to produce potent reductions in apoB and LDL-cholesterol levels in animal models as well as healthy human volunteers. A randomized, double-blind, placebo-controlled, dose-escalation study was designed to evaluate the efficacy ...See full text at original site
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引用元:
https://doi.org/10.1093/eurheartj/ehr148

データ提供:米国国立医学図書館(NLM)

Mipomersen: A New Hope for Hyperlipidemia?

This study investigates the efficacy and safety of mipomersen, an apolipoprotein (apo) B synthesis inhibitor, in treating mild-to-moderate hyperlipidemia. The research team conducted a randomized, double-blind, placebo-controlled, dose-escalation study to evaluate the effectiveness of mipomersen monotherapy with or without dose loading. The study demonstrates that mipomersen effectively reduces apoB and LDL-cholesterol levels, offering a potential new treatment option for hyperlipidemia.

Mipomersen: A Promising Treatment for Hyperlipidemia

The study shows that mipomersen, a novel apoB synthesis inhibitor, effectively lowers apoB and LDL-cholesterol levels in individuals with mild-to-moderate hyperlipidemia. This finding suggests that mipomersen could be a valuable addition to the therapeutic arsenal for managing this prevalent cardiovascular risk factor.

Managing Hyperlipidemia: A Key to Cardiovascular Health

This study underscores the importance of exploring new treatment options for hyperlipidemia, a major risk factor for heart disease. The research findings regarding mipomersen's efficacy offer hope for individuals seeking effective ways to manage their lipid levels and protect their cardiovascular health.

Dr. Camel's Conclusion

This study, like a camel seeking a fresh oasis in the desert, explores new possibilities for treating hyperlipidemia. Mipomersen, a novel apoB synthesis inhibitor, appears to offer a promising solution for managing this common condition, potentially leading to improved cardiovascular health for many individuals.
Date :
  1. Date Completed 2012-01-31
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

21593041

DOI: Digital Object Identifier

10.1093/eurheartj/ehr148

Related Literature

SNS
PICO Info
in preparation
Languages

English

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