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Effects of the levonorgestrel-releasing intrauterine system plus estrogen therapy in perimenopausal and postmenopausal women: systematic review and meta-analysis.

Author: KaewrudeeSrinaree, PannaSunida, SomboonpornWoraluk, SoontrapaSukree, TemtanakitpaisanTeerayut

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review of six randomized controlled trials compared the effects of the LNG-IUS with those of systemic progestogen in perimenopausal and postmenopausal women taking ET. The LNG-IUS was found to be comparable with other systemic progestogen regimens for endometrial protection, except for sequential medroxyprogesterone acetate, for which the LNG-IUS was more effective.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The objective of this study was to compare the effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) with those of systemic progestogen in perimenopausal and postmenopausal women taking systemic estrogen therapy (ET). METHODS: We searched Medline (August 8, 2009), Embase ...See full text at original site
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引用元：
https://doi.org/10.1097/gme.0b013e31821606c5

データ提供：米国国立医学図書館（NLM）

The Levonorgestrel-Releasing Intrauterine System: A Comprehensive Review

This systematic review and meta-analysis ventures into the vast desert of women's health, exploring the effectiveness and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) in perimenopausal and postmenopausal women taking estrogen therapy (ET). The review compares the effects of the LNG-IUS with those of systemic progestogen, analyzing data from six randomized controlled trials with a total of 518 participants. The review finds that the LNG-IUS is comparable to other systemic progestogen regimens in providing endometrial protection and effectively relieving climacteric symptoms in women taking ET. However, the review highlights the importance of addressing the potential for vaginal bleeding and spotting during the initial months of LNG-IUS use.

LNG-IUS: A Safe and Effective Option for Perimenopausal and Postmenopausal Women

The review, like a camel discovering a lush oasis in a desert landscape, reveals the effectiveness and safety of the LNG-IUS for perimenopausal and postmenopausal women taking ET. The review demonstrates that the LNG-IUS is comparable to other systemic progestogen regimens in providing endometrial protection and effectively relieving climacteric symptoms. This finding highlights the potential of the LNG-IUS as a safe and effective option for managing hormonal changes and associated symptoms in these women.

Navigating the Desert of Menopause with the LNG-IUS

This review offers valuable insights for women navigating the desert of menopause. The review highlights the potential benefits of the LNG-IUS in providing endometrial protection, relieving climacteric symptoms, and offering a safe and effective alternative to systemic progestogen regimens. However, the review also emphasizes the importance of addressing the potential for vaginal bleeding and spotting during the initial months of LNG-IUS use. This information can help women make informed decisions about their reproductive health and manage the challenges associated with menopause.

Dr. Camel's Conclusion

This comprehensive review, like a camel traversing a vast and arid desert landscape, explores the effectiveness and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) in perimenopausal and postmenopausal women taking estrogen therapy (ET). The review highlights the LNG-IUS's potential as a safe and effective option for managing hormonal changes and associated symptoms in these women, offering a valuable tool for navigating the challenges associated with menopause.

Date :
  1. Date Completed 2012-02-07
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21720280

DOI: Digital Object Identifier

10.1097/gme.0b013e31821606c5

Related Literature

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・Effects of levonorgestrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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