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Are the results of multiple drilling and alendronate for osteonecrosis of the femoral head better than those of multiple drilling? A pilot study.

Author: KangPengde, PeiFuxing, ShenBin, YangJing, ZhouZongke

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates whether combining multiple drilling core decompression with alendronate, a medication used to treat osteoporosis, is effective in delaying or preventing the progression of osteonecrosis of the femoral head (ONFH) compared to multiple drilling alone.
Paper Details　
Original Abstract of the Article :
The treatment of osteonecrosis of the femoral head (ONFH) remains controversial. A recently proposed treatment is multiple drilling core decompression combined with systemic alendronate as a femoral head-preserving procedure for ONFH. However, it is not known whether alendronate enhances the risk of...See full text at original site
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引用元：
https://doi.org/10.1016/j.jbspin.2011.02.020

データ提供：米国国立医学図書館（NLM）

Comparing Multiple Drilling and Alendronate for Osteonecrosis of the Femoral Head

This study explores the potential benefits of combining multiple drilling core decompression with systemic alendronate treatment for osteonecrosis of the femoral head (ONFH). The researchers conducted a pilot study to compare the outcomes of this combined approach to multiple drilling alone. Their findings provide valuable information on the potential efficacy and safety of this treatment strategy.

Assessing the Efficacy of Combined Treatment for Osteonecrosis of the Femoral Head

The study's findings suggest that combining multiple drilling with alendronate may be a promising treatment strategy for ONFH. The researchers observed that this combined approach may delay or prevent progression of ONFH, potentially leading to better long-term outcomes. However, the study also raises concerns about the potential for alendronate to increase the risk of femoral head collapse, highlighting the need for further research into the optimal use of this medication in ONFH treatment.

Understanding the Role of Alendronate in ONFH Treatment

This study underscores the need for careful consideration when using alendronate in the treatment of ONFH. While this medication may offer potential benefits in delaying or preventing disease progression, its potential to increase the risk of collapse warrants careful monitoring and further investigation. The researchers recommend further clinical trials to evaluate the efficacy and safety of alendronate in ONFH treatment, optimizing its use for improved patient outcomes.

Dr. Camel's Conclusion

This research reminds us that even in the vast and challenging desert of bone disease research, there are oases of hope. Understanding the optimal use of medications like alendronate is crucial for developing effective treatments for ONFH, leading to improved outcomes for patients struggling with this debilitating condition.

Date :
  1. Date Completed 2012-05-15
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

21742531

DOI: Digital Object Identifier

10.1016/j.jbspin.2011.02.020

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・Effective treatment of osteonecrosis
SNS
PICO Info
in preparation
Languages

English

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