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Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography.

Author: AschoffRoland, BräutigamMatthias, KnuschkePeter, KochEdmund, MeurerMichael, SchmittJochen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hydrocortisone 1% cream caused transient epidermal thinning after 2 weeks of treatment, while pimecrolimus 1% cream did not significantly affect epidermal thickness. This suggests that pimecrolimus may be safer for treating atopic dermatitis in sensitive areas.
Paper Details　
Original Abstract of the Article :
Topical corticosteroids are widely used to treat atopic dermatitis (AD), but their anti-inflammatory mode of action can be accompanied by several unwanted side effects including skin atrophy and telangiectasia. In this 8-week, investigator-blinded, intraindividual right-left comparison study with pa...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1600-0625.2011.01335.x

データ提供：米国国立医学図書館（NLM）

Navigating the Terrain of Topical Corticosteroids

This study delves into the world of topical corticosteroids, a common treatment for atopic dermatitis (AD). The researchers, like skilled desert guides, are exploring the impact of these medications on the skin, seeking to understand their potential benefits and risks. They compare the effects of hydrocortisone cream and pimecrolimus cream on the skin, using advanced imaging techniques to assess their impact on epidermal and dermal thickness.

Navigating the Desert of Skin Treatment Options

This study highlights the importance of considering the potential side effects of topical corticosteroids, particularly in sensitive areas like the face. It suggests that pimecrolimus cream, which has a different mechanism of action, might be a safer option for long-term use. This is like finding a hidden path through a treacherous desert landscape, offering a safer and more effective route for treating atopic dermatitis.

Finding the Right Path in the Desert of Skin Care

This study underscores the need for individualized approaches to skin care, taking into account the potential risks and benefits of different treatment options. It emphasizes the importance of understanding the unique needs and characteristics of each patient's skin. This is like navigating a vast desert, carefully assessing the terrain to find the best path for each individual traveler.

Dr. Camel's Conclusion

This study provides valuable insights into the complex terrain of topical corticosteroid therapy. It highlights the importance of considering both the benefits and risks of these medications and encourages a personalized approach to skin care. Just like a skilled desert guide, healthcare providers can help patients navigate the complexities of skin treatment and find the most effective and safe approach for their individual needs.

Date :
  1. Date Completed 2012-01-16
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

21771098

DOI: Digital Object Identifier

10.1111/j.1600-0625.2011.01335.x

Related Literature

Article Analysis
・Side Effects of pimecrolimus topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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