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Gastrointestinal disturbances and their management in miglustat-treated patients.

Author: BelmatougNadia, BurlinaAlberto, GiraldoPilar, HendrikszChris J, KuterDavid J, MengelEugen, PastoresGregory M

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
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Overview

Miglustat is a treatment for Gaucher disease and Niemann-Pick disease type C. While effective, gastrointestinal disturbances are a common side effect. These disturbances, mainly diarrhoea, are often mild and manageable through dietary modifications, anti-propulsive medications, and dose escalation.
Paper Details　
Original Abstract of the Article :
Miglustat (Zavesca®) is approved for the oral treatment of adult patients with mild to moderate type 1 Gaucher disease (GD1) for whom enzyme replacement therapy is unsuitable, and for the treatment of progressive neurological manifestations in adult and paediatric patients with Niemann-Pick disease ...See full text at original site
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引用元：
https://doi.org/10.1007/s10545-011-9368-7

データ提供：米国国立医学図書館（NLM）

Navigating the Gastrointestinal Side Effects of Miglustat

Miglustat, a medication used to treat certain types of genetic disorders, can cause gastrointestinal side effects, creating a challenge for patients seeking relief. This study delves into the desert of miglustat treatment, focusing on understanding the gastrointestinal disturbances associated with this medication. The authors explore the mechanisms behind these side effects and provide practical recommendations for managing them.

Gastrointestinal Side Effects: A Common Challenge with Miglustat

The study reveals that gastrointestinal disturbances, such as diarrhea, flatulence, and abdominal pain, are common side effects of miglustat. The authors explain that these side effects are often mild or moderate and tend to subside over time.

Managing the Gastrointestinal Oasis

The study offers valuable strategies for managing gastrointestinal side effects of miglustat, including dietary modifications, medication adjustments, and lifestyle changes. This information empowers patients to actively manage their treatment and improve their overall well-being.

Dr.Camel's Conclusion

This study delves into the challenges of managing gastrointestinal side effects associated with miglustat treatment. The authors provide valuable insights into the mechanisms behind these side effects and offer practical recommendations for mitigating their impact. By understanding these side effects and implementing appropriate management strategies, patients can optimize their treatment and enhance their overall well-being.

Date :
  1. Date Completed 2012-01-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21779792

DOI: Digital Object Identifier

10.1007/s10545-011-9368-7

Related Literature

Article Analysis
・Side Effects of miglustat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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