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Current considerations for the treatment of severe chronic pain: the potential for tapentadol.

Author: AlegreCayetano, AlénJaime Calvo, BlakeDavid, CaporaliRoberto, CasserHans-Raimund, Correa-IllanesGerardo, FernandesPedro, GalileaEugenio, JanyRichard, JonesAnthony, MejjadOthmane, Morovic-VerglesJadranka, Oteo-ÁlvaroÁngel, PergolizziJoseph, Radrigán ArayaFrancisco J, SimõesMaria Eugénia C, UomoGeneroso, ÁlvaroÁngel Oteo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tapentadol, a novel analgesic combining μ-opioid receptor agonism and noradrenaline reuptake inhibition, shows promise for treating chronic pain. Preclinical and clinical trials suggest that tapentadol offers similar efficacy to oxycodone with fewer gastrointestinal side effects and lower discontinuation rates, providing a potential alternative to current analgesics.
Paper Details　
Original Abstract of the Article :
Studies suggest that around 20% of adults in Europe experience chronic pain, which not only has a considerable impact on their quality of life but also imposes a substantial economic burden on society. More than one-third of these people feel that their pain is inadequately managed. A range of analg...See full text at original site
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引用元：
https://doi.org/10.1111/j.1533-2500.2011.00487.x

データ提供：米国国立医学図書館（NLM）

Tapentadol for Severe Chronic Pain: A Potential New Treatment

This research investigates the potential of tapentadol, a novel analgesic drug, in treating severe chronic pain. The study discusses the limitations of current pain management strategies, including the frequent reliance on nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids, which can have significant side effects and limitations. The authors highlight the unique mechanism of action of tapentadol, which combines μ-opioid receptor agonism and noradrenaline reuptake inhibition, offering a potentially more effective and tolerable approach to managing chronic pain.

A New Approach to Chronic Pain Management

The study emphasizes the potential of tapentadol to overcome some of the limitations of current pain medications, particularly in managing chronic pain. Preclinical testing suggests that tapentadol's μ-opioid receptor agonism primarily targets acute pain, while its noradrenaline reuptake inhibition is more effective for chronic pain. Clinical trials have shown that tapentadol is as effective as oxycodone in relieving chronic pain, but with significantly fewer gastrointestinal side effects and treatment discontinuations.

Hope for Better Pain Management

The study offers hope for improved pain management strategies for individuals suffering from chronic pain. The unique mechanism of action of tapentadol, combined with its demonstrated efficacy and tolerability, suggests that it may be a valuable addition to the arsenal of pain medications. It’s like finding a new oasis in the desert, offering a source of relief and hope for those seeking effective pain management.

Dr. Camel's Conclusion

This research explores the potential of tapentadol as a promising new option for treating severe chronic pain, offering a glimmer of hope for those seeking effective and well-tolerated pain management strategies. Like a camel seeking a cool respite in the desert, individuals with chronic pain deserve access to effective treatments that improve their quality of life.

Date :
  1. Date Completed 2013-02-20
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21797962

DOI: Digital Object Identifier

10.1111/j.1533-2500.2011.00487.x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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