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Effects of chlorambucil and therapeutic decision in initial forms of chronic lymphocytic leukemia (stage A): results of a randomized clinical trial on 612 patients. The French Cooperative Group on Chronic Lymphocytic Leukemia.

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Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 612 patients with chronic lymphocytic leukemia found that untreated patients with good prognosis (stage A) had better overall survival compared to those treated with chlorambucil, although the difference was not statistically significant. Chlorambucil slowed down disease progression but was associated with shorter survival after disease progression. The study suggests that patients with stage A, hemoglobin levels greater than or equal to 120 g/L, and a lymphocyte count less than 30 x 10(9)/L may not require treatment unless disease progression is observed.
Paper Details　
Original Abstract of the Article :
In 1980, the French Cooperative Group on Chronic Lymphocytic Leukemia started a randomized clinical trial in which 612 good prognosis patients (stage A) received either no treatment (309 patients) or an indefinite course of chlorambucil at the daily dose of 0.1 mg/kg (303 patients). Overall survival...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2180492

データ提供：米国国立医学図書館（NLM）

Chlorambucil: A Complex Treatment for Stage A Chronic Lymphocytic Leukemia

The management of [chronic lymphocytic leukemia (CLL)] is a complex and evolving field. This randomized clinical trial investigated the effectiveness of [chlorambucil] in treating [stage A CLL] patients. The researchers compared the outcomes of [treated and untreated groups] and found that [chlorambucil] had a [complex effect], delaying [disease progression] but potentially having [harmful effects] on [survival and cancer incidence]. These findings emphasize the importance of carefully considering the [risks and benefits] of [chlorambucil] therapy for [stage A CLL] patients.

Chlorambucil: A Double-Edged Sword for Stage A Chronic Lymphocytic Leukemia

The study reveals the complex nature of [chlorambucil] treatment for [stage A CLL]. The [beneficial effects] in [delaying disease progression] are balanced by the potential [harmful effects] on [survival and cancer incidence]. This highlights the importance of careful patient selection and individualized treatment plans for achieving optimal outcomes.

Navigating the Desert of Leukemia: Choosing the Right Path for Stage A CLL

The desert of [leukemia] can be a formidable terrain, with patients facing complex treatment decisions. This study provides valuable insights into the effects of [chlorambucil] for [stage A CLL] patients. It's like navigating a desert landscape with multiple paths, some potentially more dangerous than others.

Dr.Camel's Conclusion

The study emphasizes the importance of carefully weighing the [risks and benefits] of [chlorambucil] treatment for [stage A CLL]. It's like navigating a desert landscape, where choosing the wrong path can lead to unintended consequences. This research underscores the importance of personalized treatment plans and careful monitoring for optimal outcomes.

Date :
  1. Date Completed 1990-05-04
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

2180492

DOI: Digital Object Identifier

S0006-4971(20)83160-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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