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Differential effects of oral doxercalciferol (Hectorol) or paricalcitol (Zemplar) in the Cyp27b1-null mouse model of uremia.

Author: AkhouayriOmar, ArabianAlice, KnutsonJoyce C, St-ArnaudRené, StrugnellStephen A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed an animal model with complete calcitriol deficiency to evaluate vitamin D analogs in uremia.
Paper Details　
Original Abstract of the Article :
Kidney disease patients experience declining calcitriol levels and develop secondary hyperparathyroidism (SHPT). Animal models of uremia based on 5/6 nephrectomy (NTX) do not consistently reproduce this calcitriol deficiency. We developed an animal model, the NTX Cyp27b1-null mouse, which completely...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1159/000329663

データ提供：米国国立医学図書館（NLM）

Calcitriol Deficiency in Uremia: A New Animal Model

Kidney disease, like a slow desert wind, can erode the body's vital functions. This study explores the challenges of modeling calcitriol deficiency, a common complication of kidney disease, in laboratory animals.

Developing a Novel Animal Model: Addressing the Gap

The researchers developed a new animal model, the NTX Cyp27b1-null mouse, which completely lacks endogenous calcitriol, the active form of vitamin D. This is like discovering a new desert environment with unique characteristics that allow us to study specific ecological phenomena.

Evaluating Vitamin D Analogs: A Crucial Step

The new animal model provides a valuable tool for evaluating the effectiveness of vitamin D analogs in treating calcitriol deficiency and secondary hyperparathyroidism, a common complication of kidney disease. This is like finding a new and effective source of water in the desert, offering a solution to the challenges of hydration and survival.

Dr. Camel's Conclusion

The development of the NTX Cyp27b1-null mouse model provides a significant advancement in understanding and treating calcitriol deficiency in kidney disease. This new model opens up exciting avenues for research and development of new therapies to address the specific challenges of this debilitating condition.
Date :
  1. Date Completed 2015-06-22
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

21849802

DOI: Digital Object Identifier

10.1159/000329663

Related Literature

Article Analysis
・Effects of doxercalciferol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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