A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers.

Author: AlbaughVance L, LynchChristopher J, MaugerDavid, SingareddyRavi

Paper Details 
Original Abstract of the Article :
Atypical antipsychotics exhibit metabolic side effects including diabetes mellitus and obesity. The adverse events are preceded by acute worsening of oral glucose tolerance (oGTT) along with reduced plasma free fatty acids (FFA) and leptin in animal models. It is unclear whether the same acute effec...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153475/

データ提供:米国国立医学図書館(NLM)

The Metabolic Effects of Olanzapine in Humans

Atypical antipsychotics are medications that are commonly used to treat mental health conditions like schizophrenia and bipolar disorder. While they are generally effective, one of the challenges with these drugs is that they can cause significant metabolic side effects. This is particularly important, given the ever-growing prevalence of metabolic diseases such as diabetes and obesity. These metabolic side effects can be quite troublesome, as they can lead to a decrease in the quality of life and an increased risk of chronic health conditions. This study is investigating the potential for metabolic effects of olanzapine, a specific atypical antipsychotic, in healthy volunteers.

Exploring the Immediate Effects of Olanzapine

This study is designed to investigate the acute (short-term) metabolic effects of olanzapine in healthy volunteers. The researchers are looking for clues about how olanzapine might affect the way the body uses and stores energy, particularly focusing on glucose tolerance. This research is particularly important as it attempts to bridge the gap between what we know about the metabolic effects of olanzapine in animal studies and how it might manifest in humans.

Implications for Understanding Antipsychotic Side Effects

The findings of this study could have significant implications for understanding the metabolic side effects of olanzapine and other atypical antipsychotics. It could help us develop safer and more effective treatments for mental health conditions without compromising the health of our patients. The study's findings may guide the development of new drugs with fewer metabolic side effects or help us understand the risks associated with current medications.

Dr.Camel's Conclusion

This study delves into the fascinating world of atypical antipsychotics and their potential metabolic effects. Just like camels are adapted to survive the harsh desert environment, it's essential to understand the nuances of these medications and their potential impact on human health. This research is a step towards ensuring safe and effective treatment for mental health conditions while minimizing the risk of metabolic side effects.
Date :
  1. Date Completed 2012-02-15
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

21857944

DOI: Digital Object Identifier

PMC3153475

Related Literature

SNS
PICO Info
in preparation
Languages

English

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