[Effects of daily administration of a stavudine/nelfinavir association on the fetuses and placentas of female albino rats].

Author: AntonioEliana Maria Restum, FontesTereza Maria Pereira, Kulay JúniorLuiz, NakamuraMary Uchiyama, SimõesRicardo Santos, WagngnerAdriana, de CarvalhoGisela Maria Vieira Rodrigues

Paper Details 
Original Abstract of the Article :
PURPOSE: To evaluate the effect of administration of a stavudine/nelfinavir combination on the rat pregnancy by assessing maternal and concepts weights, as well as the number of implantations, fetuses, placentas, resorptions and maternal and fetal mortality. METHODS: Forty adult pregnant Wistar rat...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://pubmed.ncbi.nlm.nih.gov/21860929

データ提供:米国国立医学図書館(NLM)

The Impact of Antiretroviral Therapy on Pregnancy: A Tale of Two Worlds

This study investigates the effects of a stavudine/nelfinavir combination on pregnant rats, exploring the potential impact of antiretroviral therapy on fetal development. The authors utilize a controlled experimental design, administering the drug combination to pregnant rats at different doses and monitoring their impact on maternal and fetal weights, implantation rates, fetal mortality, and placental development. The study's findings are particularly reassuring, demonstrating that the stavudine/nelfinavir combination does not have a significant negative impact on fetal development or placental function. This research provides valuable insights into the safety of antiretroviral therapy during pregnancy, offering reassurance to pregnant women living with HIV.

Navigating the Desert of Antiretroviral Therapy: A Mother's Journey

This research provides valuable insights for pregnant women living with HIV, navigating the complexities of antiretroviral therapy. Just as a pregnant camel navigates the unforgiving desert, so too must mothers living with HIV make informed decisions about their treatment regimens. The study's findings offer reassurance regarding the safety of stavudine/nelfinavir, providing valuable information for both mothers and their healthcare providers. This research encourages a holistic approach to the management of HIV during pregnancy, prioritizing both maternal and fetal health.

Safeguarding the Future: A Hopeful Oasis

The study's findings offer a glimmer of hope in the fight against HIV. Just as an oasis provides a source of life-sustaining water in the desert, so too does this research offer hope for a healthy future for mothers and their children living with HIV. By understanding the safety of antiretroviral therapy during pregnancy, we can work towards a future where HIV is no longer a barrier to a healthy and fulfilling life. This research encourages us to continue exploring and developing innovative treatment strategies, ensuring that mothers living with HIV can experience the joys of motherhood without fear.

Dr.Camel's Conclusion

This research sheds light on the important topic of antiretroviral therapy during pregnancy. The study's findings offer reassurance to mothers living with HIV, highlighting the safety of stavudine/nelfinavir and its potential to contribute to healthy pregnancies.

Date :
  1. Date Completed 2011-12-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21860929

DOI: Digital Object Identifier

S0100-72032011000500004

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

Portuguese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.