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Formulation and evaluation of solid lipid nanoparticles of ramipril.

Author: AbdulHasan Sathali A, EkambaramP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Solid lipid nanoparticles (SLNs) were formulated to enhance the bioavailability and reduce side effects of ramipril, an antihypertensive drug with 28% oral bioavailability and rapid renal excretion. The study developed SLNs using various lipids and stabilizers, evaluating their properties like entrapment efficiency, drug release, and particle size. The SLNs containing glyceryl monooleate stabilized with span 20 demonstrated prolonged drug release, smaller particle size, and narrow particle size distribution compared to other formulations.
Paper Details　
Original Abstract of the Article :
Solid lipid nanoparticles are typically spherical with an average diameter between 1 and 1000 nm. It is an alternative carrier system to tradition colloidal carriers, such as, emulsions, liposomes, and polymeric micro and nanoparticles. Ramipril is an antihypertensive agent used in the treatment of ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159275/

データ提供：米国国立医学図書館（NLM）

Ramipril: A New Delivery System for an Antihypertensive Drug

Ramipril is a widely used antihypertensive drug, helping to control high blood pressure. However, traditional oral formulations of ramipril can lead to side effects like postural hypotension and hyperkalemia. This study explores the potential of solid lipid nanoparticles (SLNs) as a novel delivery system for ramipril, aiming to improve its bioavailability and reduce its side effects.

Solid Lipid Nanoparticles: A Revolutionary Delivery System

The researchers successfully formulated SLNs of ramipril using different lipids and stabilizers. They evaluated the formulations in terms of drug entrapment, drug content, and in vitro drug release. This study suggests that SLNs could offer a way to improve the delivery and efficacy of ramipril, potentially reducing its side effects. It's like creating a new water source in the desert, ensuring a smoother and more efficient journey for the medication.

A Smoother Ride for Ramipril: Improving Patient Outcomes

This research has the potential to improve patient outcomes by enhancing the delivery of ramipril. It's like finding a new camel breed that can better navigate challenging terrain - a promising step towards more effective and safer treatment options.

Dr.Camel's Conclusion

This study presents a novel approach to delivering ramipril, potentially minimizing its side effects. It's like a camel caravan discovering a hidden oasis, promising a more comfortable and effective journey for patients.

Date :
  1. Date Completed 2011-11-10
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

21897661

DOI: Digital Object Identifier

PMC3159275

Related Literature

Article Analysis
・Side Effects of ramipril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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