The effects of D-penicillamine on a murine model of oxygen-induced retinopathy.

Author: AshJohn D, MoreauAnnie, SiatkowskiR Michael, YanovitchTammy L

Paper Details 
Original Abstract of the Article :
PURPOSE: To determine the effect of intraperitoneal and intravitreal D-penicillamine (DPA) on retinal neovascularization in a murine model of oxygen-induced retinopathy. METHODS: On postnatal day 7, 16 mice were injected intraperitoneally with 300 mg/kg/day DPA for 3 days followed by 50 mg/kg/day f...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/21907121

データ提供:米国国立医学図書館(NLM)

D-Penicillamine and Oxygen-Induced Retinopathy: A Murine Model

Oxygen-induced retinopathy (OIR), a condition affecting the retina, is a complex medical challenge. This study investigates the potential of D-penicillamine (DPA), a drug commonly used to treat certain diseases, as a treatment for OIR in a murine model. The study aimed to determine whether DPA could inhibit the growth of new blood vessels in the retina, a hallmark of OIR.

D-Penicillamine and Retinal Neovascularization: Exploring the Possibilities

The study involved administering DPA to mice with OIR through different routes, including intraperitoneal and intravitreal injections. However, the results showed no significant reduction in retinal neovascularization, indicating that DPA may not be an effective treatment for OIR. It's like searching for a hidden oasis in the desert, only to discover that the water source has dried up.

The Search Continues: Uncovering New Solutions for OIR

This study, while not showing promising results for DPA, highlights the ongoing need for research into effective treatments for OIR. It's a reminder that the vast desert of medical research is constantly evolving, with new pathways to explore and new solutions to uncover. Further research is needed to identify alternative therapies that can effectively address the challenges of OIR.

Dr.Camel's Conclusion

The search for effective treatments for OIR continues, with this study offering valuable insights into the potential and limitations of DPA. It's a testament to the relentless pursuit of knowledge in the medical field, where even seemingly promising avenues may lead to dead ends, but the journey itself remains a valuable learning experience. The quest for new solutions for OIR continues, driven by the unwavering commitment to improving the health and well-being of patients.

Date :
  1. Date Completed 2012-01-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21907121

DOI: Digital Object Identifier

NIHMS380135

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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