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Lipid-drug interaction: biophysical effects of tolmetin on membrane mimetic systems of different dimensionality.

Author: BrezesinskiGerald, LimaJosé L F C, LopesDaniela, LúcioMarlene, NunesCláudia, ReisSalette

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tolmetin, a nonsteroidal anti-inflammatory drug (NSAID), interacts with lipid membranes, and its interaction is strongly dependent on the degree of drug ionization and the lipid phase state.
Paper Details　
Original Abstract of the Article :
This work focuses on the application of different biophysical techniques to study the interaction of tolmetin with membrane mimetic models of different dimensionality (liposomes, monolayers, and supported lipid bilayers) composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), used as a repre...See full text at original site
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引用元：
https://doi.org/10.1021/jp206013z

データ提供：米国国立医学図書館（NLM）

Tolmetin and Its Interactions with Lipid Membranes: A Biophysical Perspective

This study investigates the biophysical effects of tolmetin, a nonsteroidal anti-inflammatory drug (NSAID), on membrane mimetic systems of different dimensionality. By employing various biophysical techniques, researchers explore how tolmetin interacts with lipid membranes, providing a deeper understanding of its mechanism of action and potential side effects.

Tolmetin's Interactions with Membranes: A Complex Dance

The study found that tolmetin's interaction with lipid membranes is highly dependent on its ionization state and the phase state of the lipid. This research underscores the complexity of drug-membrane interactions and their implications for drug efficacy and toxicity.

Navigating the World of NSAIDs: A Biophysical Perspective

This study highlights the importance of understanding the biophysical interactions of drugs with cellular membranes. By gaining insights into these complex interactions, we can better predict drug efficacy, minimize side effects, and develop safer and more effective medications.

Dr.Camel's Conclusion

The human body is a wondrous and complex desert, filled with intricate membranes that play vital roles in maintaining health. This study takes us on a biophysical journey, exploring the interactions of tolmetin with these membranes, shedding light on the intricacies of drug action and providing valuable insights for future drug development.

Date :
  1. Date Completed 2012-03-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21936545

DOI: Digital Object Identifier

10.1021/jp206013z

Related Literature

Article Analysis
・Effects of tolmetin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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