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Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies.

Author: AmbrusJ L, AnainJ M, AnainP M, AnainS M, BrobstJ A, CobertB L, MitchellP, SavitskyJ P, StadlerS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pentoxifylline was found to increase red cell filterability in patients with chronic occlusive arteriosclerosis in a dose-response manner. Increases in red cell filterability were proportional to plasma levels of pentoxifylline and its metabolites.
Paper Details　
Original Abstract of the Article :
Ten patients with chronic occlusive arteriosclerosis received single oral doses of 100, 200, 400, 800, and 1200 mg pentoxifylline in a single-blind, placebo-controlled study. Blood samples were drawn at baseline and at 2 hour intervals for 6 hours. Drug and metabolite levels, as well as red cell fil...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1990.117

データ提供：米国国立医学図書館（NLM）

Pentoxifylline's Impact on Red Blood Cell Flexibility: A Dose-Response Study

The human body is a complex system of interconnected parts, like a vast desert with intricate pathways. This research explores the impact of pentoxifylline, a medication often used to improve blood flow, on red blood cell flexibility, a crucial factor in cardiovascular health. The researchers conducted a dose-response study to determine the relationship between pentoxifylline dosage and red blood cell deformability in patients with chronic occlusive arteriosclerosis.

Pentoxifylline Improves Red Blood Cell Flexibility

The findings of this research indicate that pentoxifylline significantly improves red blood cell flexibility in patients with chronic occlusive arteriosclerosis. The researchers observed a dose-dependent increase in red blood cell deformability, suggesting that pentoxifylline's effectiveness is directly related to the dosage administered. This study provides valuable insights into the mechanism of action of pentoxifylline and its potential benefits in improving blood flow.

Implications for Blood Flow and Vascular Health

This research highlights the importance of red blood cell flexibility in maintaining cardiovascular health. The study's findings suggest that pentoxifylline, by enhancing red blood cell deformability, could potentially improve blood flow and reduce the risk of vascular complications. This research underscores the crucial role of red blood cell flexibility in the overall health of the cardiovascular system.

Dr. Camel's Conclusion

This research underscores the importance of red blood cell flexibility in the vast desert of the human circulatory system. Pentoxifylline, like a camel navigating a challenging desert landscape, appears to enhance red blood cell flexibility, potentially improving blood flow and contributing to cardiovascular health. This research encourages further exploration of pentoxifylline's role in managing conditions affecting blood flow and vascular health.

Date :
  1. Date Completed 1990-08-22
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2196145

DOI: Digital Object Identifier

10.1038/clpt.1990.117

SNS
PICO Info
in preparation
Languages

English

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