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Three-year growth hormone treatment in short children with X-linked hypophosphatemic rickets: effects on linear growth and body disproportion.

Author: , BeetzR, BillingH, EvenG, FischerD-C, HaffnerD, HiortO, HolderM, MarxM, RablW, SchnabelD, SchumacherM, StaudeH, ŽivičnjakM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Growth hormone (GH) treatment improved linear growth in short children with X-linked hypophosphatemic rickets (XLH) without worsening body disproportion. The study found sustained increases in stature, sitting height, leg length, and arm length in GH-treated patients compared to controls. This suggests that GH may be a beneficial treatment for short stature in children with XLH.
Paper Details　
Original Abstract of the Article :
CONTEXT: Children with X-linked hypophosphatemic rickets (XLH) are prone to progressive disproportionate stunting despite oral phosphate and vitamin D treatment. OBJECTIVE: Our objective was to analyze the effects of GH treatment on stature and lengths of linear body segments in short children with...See full text at original site
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引用元：
https://doi.org/10.1210/jc.2011-0399

データ提供：米国国立医学図書館（NLM）

Growth Hormone and XLH: Shaping the Landscape of Growth

X-linked hypophosphatemic rickets (XLH) is a rare genetic disorder that affects bone growth. It's like trying to build a sturdy sandcastle in a desert where the sand keeps shifting. Children with XLH often experience stunted growth and disproportionate body shapes. This study investigates the effects of growth hormone (GH) treatment on children with XLH, exploring its potential to improve growth and body proportions.

Growth Hormone's Impact: Building a Stronger Sandcastle

The researchers found that GH treatment led to a sustained increase in linear growth in children with XLH, improving their height, leg length, and arm length. While GH didn't completely resolve the body disproportion, it did help to improve these physical characteristics. It's like finding a way to stabilize the sand and build a more robust sandcastle, even in a challenging desert environment.

A Journey Toward Healthy Growth

This study provides hope for children with XLH, offering a potential treatment option to improve their growth and body proportions. It's like finding a new oasis that provides resources for healthy growth and development. Further research is needed to fully understand the long-term effects of GH treatment and explore other potential therapeutic interventions.

Dr.Camel's Conclusion

This study provides a valuable glimpse into the potential of GH treatment for children with XLH. It's like discovering a new way to build a more robust sandcastle in a shifting desert. While more research is needed, this study offers hope for a brighter future for children living with this challenging condition.

Date :
  1. Date Completed 2012-02-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21994957

DOI: Digital Object Identifier

10.1210/jc.2011-0399

Related Literature

Article Analysis
・Effective treatment of rickets
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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