The B-Raf status of tumor cells may be a significant determinant of both antitumor and anti-angiogenic effects of pazopanib in xenograft tumor models.

Author: AnwarTalha, BernardoMarcelino, ChoykePeter, GrilBrunilde, IlevaLilia, LiewehrDavid J, PalmieriDiane, QianYong, SteegPatricia S, SteinbergSeth M

Paper Details 
Original Abstract of the Article :
Pazopanib is an FDA approved Vascular Endothelial Growth Factor Receptor inhibitor. We previously reported that it also inhibits tumor cell B-Raf activity in an experimental brain metastatic setting. Here, we determine the effects of different B-Raf genotypes on pazopanib efficacy, in terms of prima...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187787/

データ提供:米国国立医学図書館(NLM)

Pazopanib: A Targeted Therapy for B-Raf-Driven Cancers

This study delves into the exciting world of [targeted cancer therapies], focusing on the drug [pazopanib]. The researchers investigated the effect of [pazopanib] on different types of [cancer cells] with varying mutations in the [B-Raf] gene. They found that [pazopanib] was particularly effective in inhibiting [tumor growth] in cells with specific [B-Raf] mutations. This discovery highlights the potential of [pazopanib] as a targeted therapy for certain types of [cancer].

Precision Medicine: Tailoring Treatments to Individual Needs

This study underscores the growing importance of [precision medicine] in cancer treatment. By understanding the specific genetic makeup of a tumor, doctors can choose the most effective treatment for each individual patient. This approach has the potential to improve treatment outcomes and minimize side effects.

Cancer Treatment: A Personal Journey

This research offers a glimmer of hope for patients with certain types of [cancer]. However, it's crucial to remember that [cancer treatment] is a personal journey that requires ongoing monitoring and collaboration between patients and healthcare professionals. Open communication and a personalized approach can empower patients to make informed decisions about their treatment and maximize their chances of a successful outcome.

Dr.Camel's Conclusion

This study is like a compass guiding us through the vast desert of [cancer research]. By targeting specific genetic mutations, we can personalize treatment and navigate towards a brighter future for patients!

Date :
  1. Date Completed 2012-02-13
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

21998674

DOI: Digital Object Identifier

PMC3187787

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Languages

English

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