Additive diuretic response of concurrent aminophylline and furosemide in children: a case series and a brief literature review.

Author: FonsecaMarcelo Cunio Machado, da SilvaPaulo Sérgio Lucas, de AguiarVânia Euzébio

Paper Details 
Original Abstract of the Article :
Aminophylline exerts a renovascular effect, acting by adenosine receptor blockade or type IV phosphodiesterase inhibition. Clinically, these drugs have been used with furosemide to induce diuresis in adults and neonates. However, reports on use of aminophylline in diuretic-dependent children are lim...See full text at original site
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引用元:
https://doi.org/10.1007/s00540-011-1250-0

データ提供:米国国立医学図書館(NLM)

Boosting Diuresis in Children: Exploring the Synergy of Aminophylline and Furosemide

Fluid overload can be a serious challenge in critically ill children, often requiring diuretic therapy. This study investigates the additive diuretic effect of aminophylline in combination with furosemide, a commonly used diuretic, in children unresponsive to furosemide alone. The researchers present a case series of four children who demonstrated a significant increase in urine output after receiving aminophylline in addition to furosemide. The study suggests that aminophylline, at low doses, may be a valuable adjunct to furosemide in managing fluid overload in critically ill children.

A New Path for Diuresis in Children: Aminophylline Offers Additional Benefits

This study offers a promising new avenue for managing fluid overload in critically ill children, highlighting the potential synergistic effect of aminophylline when used in combination with furosemide. The case series demonstrates a significant increase in urine output after receiving aminophylline, suggesting that this approach may be a valuable tool for treating fluid overload in children who are unresponsive to furosemide alone. These findings warrant further investigation to confirm the effectiveness and safety of this combination therapy in a larger population of children.

A Journey Through the Desert of Fluid Overload: Finding Solutions for Children

This research reminds us that the landscape of pediatric care is constantly evolving, and we must continue to explore new strategies for managing complex conditions. The potential of aminophylline as an adjunct to furosemide in treating fluid overload in children offers a glimmer of hope for those facing this challenge. This research encourages further investigation to fully understand the benefits and safety of this combination therapy, paving the way for more effective treatment options for children.

Dr.Camel's Conclusion

This research is like a refreshing spring in the desert of pediatric care. It's a reminder that even in the face of seemingly insurmountable challenges, new solutions can emerge. The potential of aminophylline to improve diuretic response in children offers a hopeful sign that we can continue to find better ways to treat those who need our care.

Date :
  1. Date Completed 2012-06-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

22005755

DOI: Digital Object Identifier

10.1007/s00540-011-1250-0

Related Literature

SNS
PICO Info
in preparation
Languages

English

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