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Oral isotretinoin in different dose regimens for acne vulgaris: a randomized comparative trial.

Author: AgarwalUma Shankar, BesarwalRaj Kumar, BholaKalyani

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

For severe acne either conventional high doses of isotretinoin may be used or we can give conventional high dose for initial eight weeks and later maintain on low doses. Use of isotretinoin should be considered in mild to moderate acne also, in low doses.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Oral isotretinoin is recommended for severe nodulocystic acne in the doses of 1-2 mg/kg/day which is usually associated with higher incidence of adverse effects. To reduce the incidence of side-effects and to make it more cost-effective, the lower dose regimen of isotretinoin has been us...See full text at original site
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引用元：
https://doi.org/10.4103/0378-6323.86482

データ提供：米国国立医学図書館（NLM）

Isotretinoin: Optimizing Treatment for Acne Vulgaris

Acne vulgaris, a common skin condition, can significantly impact an individual's self-esteem and quality of life. This study, like a camel navigating a vast and unpredictable desert, explores the efficacy and tolerability of oral isotretinoin in different dose regimens for acne vulgaris. The researchers conducted a randomized comparative trial involving 120 patients with acne, comparing the effects of daily, alternate, pulse, and low-dose isotretinoin regimens. Their findings revealed that all four treatment regimens were effective in reducing acne lesions, with the daily high dose treatment performing better initially. However, at the end of therapy, the results were comparable for the daily high dose, alternate day, and low-dose regimens. The researchers also observed that the frequency and severity of treatment-related side effects were significantly higher in the daily high dose group compared to the other groups.

Balancing Efficacy and Tolerability in Acne Treatment

The study's findings highlight the importance of balancing efficacy and tolerability in the treatment of acne vulgaris. The researchers observed that while the daily high dose isotretinoin regimen provided the most rapid improvement, it was also associated with a higher incidence of side effects. This finding suggests that a more individualized approach to isotretinoin dosing may be beneficial, with the potential to optimize treatment outcomes while minimizing adverse events.

Navigating the Treatment Options for Acne Vulgaris

The study's findings provide valuable insights into the management of acne vulgaris. The researchers' findings suggest that different isotretinoin dose regimens can be effective, with the choice of regimen being guided by the severity of acne and the patient's individual tolerance for side effects.

Dr.Camel's Conclusion

This study, like a camel navigating a vast and unpredictable desert, highlights the importance of balancing efficacy and tolerability in the treatment of acne vulgaris. The researchers' findings suggest that individualized isotretinoin dose regimens can be effective, with the potential to optimize treatment outcomes while minimizing adverse events. The camel of medicine continues to search for the perfect oasis of treatment, one that offers both efficacy and safety for patients with acne vulgaris, while striving for improved patient outcomes.

Date :
  1. Date Completed 2012-02-27
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

22016276

DOI: Digital Object Identifier

10.4103/0378-6323.86482

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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