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Prospective comparison of patient tolerance to enteric-coated vs nonenteric-coated erythromycin.

Author: ChristensenD B, EllsworthA J, Volpone-McMahonM T

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Two common erythromycin base formulations, Erythromycin Base Filmtab and Eryc, were compared in 368 adults. Minimal differences were found between the two formulations in terms of gastrointestinal side effects. However, patients receiving erythromycin at the 2-g/d dosage level reported higher incidence rates for each of the target symptoms than did those patients treated at the 1-g/d dosage level.
Paper Details　
Original Abstract of the Article :
Erythromycin base and its salts are frequently used in clinical practice. The most frequent side effects of oral erythromycin preparations are gastrointestinal. Various salts and enteric coatings have been developed without adequate comparison in regard to gastrointestinal side effects. The overall ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2202773

データ提供：米国国立医学図書館（NLM）

Enteric-Coated Erythromycin: A Comparative Study

The world of pharmaceuticals is a vast desert, with various formulations and delivery methods to navigate. This study, conducted in adults, investigated the gastrointestinal tolerance of two erythromycin formulations: Erythromycin Base Filmtab, a nonenteric-coated base tablet, and Eryc, a pelletized, encapsulated, enteric-coated base capsule. The authors compared the incidence of gastrointestinal side effects in 368 adults at two dosage levels (1 g/d and 2 g/d), seeking to determine if enteric coating provided any advantage in reducing these side effects.

Limited Benefit of Enteric Coating

This research found that enteric coating offered minimal protection from gastrointestinal adverse effects. The authors observed similar incidences of gastrointestinal side effects across both formulations, suggesting that enteric coating may not significantly improve patient tolerance to erythromycin.

Managing Erythromycin Side Effects

This study highlights the importance of understanding the potential side effects of medications. The authors' findings suggest that gastrointestinal side effects are a common occurrence with erythromycin, regardless of the formulation. Patients should be aware of these potential side effects and communicate any concerns with their healthcare providers.

Dr.Camel's Conclusion

This study, like a map through a desert of drug formulations, reveals that enteric coating may not be the magic bullet for mitigating erythromycin's gastrointestinal side effects. It emphasizes the need for careful consideration of dosage and patient-specific factors when prescribing erythromycin.

Date :
  1. Date Completed 1990-09-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2202773

DOI: Digital Object Identifier

2202773

SNS
PICO Info
in preparation
Languages

English

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