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Histamine and H1-antihistamines: celebrating a century of progress.

Author: SimonsF Estelle R, SimonsKeith J

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the history and progress of antihistamines, highlighting their clinical pharmacology, efficacy, and safety.
Paper Details　
Original Abstract of the Article :
In this review we celebrate a century of progress since the initial description of the physiologic and pathologic roles of histamine and 70 years of progress since the introduction of H(1)-antihistamines for clinical use. We discuss histamine and clinically relevant information about the molecular m...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaci.2011.09.005

データ提供：米国国立医学図書館（NLM）

Histamine and H1-Antihistamines: A Century of Progress

Histamine, a powerful chemical messenger involved in various physiological processes, has played a central role in the development of antihistamines. This study, like a historian meticulously chronicling the evolution of a scientific field, traces the journey of histamine and H1-antihistamines, celebrating a century of progress since the discovery of histamine's role in allergic reactions and 70 years since the introduction of H1-antihistamines into clinical practice. The authors delve into the molecular mechanisms of action of H1-antihistamines, providing a comprehensive understanding of their therapeutic effects and the evolution of antihistamine research.

Unlocking the Secrets of Histamine: Understanding Its Role in Allergy

The study sheds light on the complex role of histamine in allergic reactions, revealing its intricate interactions with various cellular processes. This knowledge has been instrumental in the development of H1-antihistamines, which have revolutionized the management of allergies and related conditions.

Navigating the Desert of Allergies: A Journey Through Antihistamine Development

The study traces the evolution of H1-antihistamines, highlighting the significant advancements in their design and efficacy. The authors discuss the transition from first-generation H1-antihistamines with significant side effects to newer, second-generation H1-antihistamines with improved safety profiles. This journey reflects the ongoing efforts of researchers to optimize antihistamine therapy, ensuring effective and safe treatment for allergies and related conditions.

Dr.Camel's Conclusion

This study is a testament to the enduring power of scientific inquiry in the field of allergy research. Through careful investigation, researchers have unlocked the secrets of histamine, paving the way for the development of effective and safe antihistamine therapies. This journey continues, with researchers constantly exploring new avenues to alleviate the burden of allergies and improve the quality of life for those affected.

Date :
  1. Date Completed 2012-01-19
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

22035879

DOI: Digital Object Identifier

10.1016/j.jaci.2011.09.005

SNS
PICO Info
in preparation
Languages

English

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