Paper Details

  1. Home
  2. Paper Details

The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation.

Author: DuanKaizhong, JinDi, PengJianxia, ZhangLianjun, ZhaoYong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Leflunomide, a drug for rheumatoid arthritis, was found to affect Treg cells in a mouse model of allogeneic bone marrow transplantation.
Paper Details　
Original Abstract of the Article :
Leflunomide (LEF) is effective not only in different animal models of autoimmune diseases and the therapy of patients with rheumatoid arthritisbut also in graft rejection. The effect of LEF on CD4(+)CD25(+)T regulatory cells (Treg) was determined in a mouse model of allogeneic bone marrow transplant...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00011-011-0388-4

データ提供：米国国立医学図書館（NLM）

Leflunomide: A Potential Ally in Bone Marrow Transplantation

Bone marrow transplantation, a life-saving procedure for individuals with certain blood disorders and cancers, is often accompanied by graft rejection. This happens when the recipient's immune system attacks the donor's cells, creating a complex immunological battle.

Leflunomide (LEF), a drug commonly used for rheumatoid arthritis, has shown promise in preventing graft rejection in animal models. This study investigated the effects of LEF on CD4(+)CD25(+)Foxp3(+) T regulatory cells (Treg), which play a crucial role in regulating the immune response. The study found that LEF was effective in promoting the development of Treg cells, suggesting its potential use in preventing graft rejection.

A New Frontier in Transplant Immunosuppression

The findings of this study suggest that LEF may be a valuable addition to the immunosuppressive arsenal for bone marrow transplantation.

Dr. Camel's Conclusion

Imagine a desert oasis where different tribes gather to share resources and stories. A harmonious coexistence depends on maintaining peace and understanding between the tribes. Similarly, successful bone marrow transplantation relies on establishing a balance between the recipient's immune system and the donor's cells. This study suggests that LEF may be a key player in fostering this delicate balance.

Date :
  1. Date Completed 2012-04-30
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22057872

DOI: Digital Object Identifier

10.1007/s00011-011-0388-4

Related Literature

Article Analysis
・Effects of leflunomide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.