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Hepatic effects of chlorpropamide: inhibition of glucagon-stimulated gluconeogenesis in perfused livers of fasted rats.

Author: BlumenthalS A, WhitmerK R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Chlorpropamide blocked the effects of glucagon on glucose formation in perfused rat livers. Chlorpropamide may inhibit gluconeogenesis by antagonizing the action of glucagon. The drug's effects were observed at concentrations comparable to serum concentrations in patients.
Paper Details　
Original Abstract of the Article :
In perfused livers of rats fasted for 24 h, glucagon (5 x 10(-10) M) significantly elevated tissue and perfusate levels of cyclic AMP and caused a twofold increase in glucose formation from lactate. Chlorpropamide (0.8 x 10(-3) M) consistently blocked these effects. Measurements of metabolic interme...See full text at original site
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引用元：
https://doi.org/10.2337/diab.28.7.646

データ提供：米国国立医学図書館（NLM）

Hepatic Effects of Chlorpropamide: Inhibition of Glucagon-Stimulated Gluconeogenesis

This study investigates the hepatic effects of chlorpropamide, a diabetes medication. The researchers used perfused rat livers to study the effects of chlorpropamide on gluconeogenesis, the process of producing glucose from non-carbohydrate sources. It's like exploring a desert where the body's ability to create its own water sources can be altered.

Chlorpropamide Inhibits Gluconeogenesis

The researchers found that chlorpropamide inhibited the effects of glucagon, a hormone that stimulates gluconeogenesis. This is like blocking a desert spring that provides essential water for life. The researchers discovered that chlorpropamide may inhibit gluconeogenesis by antagonizing the action of glucagon on the phosphoenolpyruvate cycle.

Health Benefits and Lifestyle Implications

This research helps to clarify the mechanism of action of chlorpropamide, providing valuable insights into the way this medication works. It's like understanding the intricate workings of a desert ecosystem, revealing the delicate balance between different elements. This information can be used to develop more effective treatments for diabetes and to optimize the use of existing medications.

Dr. Camel's Conclusion

This research sheds light on the complex interactions between hormones and metabolic processes in the liver. It's like mapping out the complex pathways of water flow in a desert. This study helps us understand the mechanisms by which chlorpropamide works, providing important information for managing diabetes and improving patient care.

Date :
  1. Date Completed 1979-09-01
  2. Date Revised 2019-05-15
Further Info :

Pubmed ID

221298

DOI: Digital Object Identifier

10.2337/diab.28.7.646

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Article Analysis
・Effects of chlorpropamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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