Dalfampridine: a new agent for symptomatic management of multiple sclerosis.

Author: ClementsJennifer N, McDonaldSarah

Paper Details 
Original Abstract of the Article :
PURPOSE The pharmacology, pharmacokinetics, clinical efficacy, safety, dosage, and place in therapy of dalfampridine are reviewed. SUMMARY Dalfampridine is a novel drug with a unique mechanism for the symptomatic management of multiple sclerosis (MS) among all classifications. Dalfampridine was appr...See full text at original site
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引用元:
https://doi.org/10.2146/ajhp110134

データ提供:米国国立医学図書館(NLM)

Dalfampridine: A New Agent for Symptomatic Management of Multiple Sclerosis

Multiple sclerosis (MS) is a chronic neurological disorder that affects the central nervous system. This study explores the use of dalfampridine, a novel drug for the symptomatic management of MS, focusing on its pharmacology, pharmacokinetics, clinical efficacy, safety, dosage, and place in therapy.

Dalfampridine works by blocking potassium channels on demyelinated neurons, allowing for normal electrical conduction and improving walking difficulties in MS patients. The study summarizes its unique mechanism of action and provides details about its absorption, metabolism, and excretion. Clinical studies have demonstrated dalfampridine's effectiveness in improving walking speed, with a recommended dosage of 10 mg orally twice daily. However, it's not appropriate for patients with seizures or moderate to severe renal impairment.

Dalfampridine: A Promising Treatment for Multiple Sclerosis

This research highlights the potential of dalfampridine for improving walking ability in MS patients. The drug's unique mechanism of action offers a new approach to managing MS symptoms, providing a potential source of relief for individuals struggling with mobility issues. The study emphasizes the need for careful monitoring and appropriate patient selection to ensure safe and effective treatment.

Managing Multiple Sclerosis Symptoms and Improving Quality of Life

This study offers hope for individuals living with MS. Dalfampridine, with its demonstrated ability to improve walking speed, presents a potential tool for managing MS symptoms and enhancing quality of life. Further research is needed to fully understand its long-term benefits and potential risks, but this research provides valuable insights into a promising new treatment option for MS patients.

Dr. Camel's Conclusion

Navigating the desert of MS can be a challenging journey. Dalfampridine offers a glimmer of hope, like a distant oasis in the sand. By improving walking ability, this drug can potentially enhance the quality of life for individuals with MS. While further exploration is needed, dalfampridine represents a promising advancement in the ongoing search for effective treatments for this complex neurological disorder.

Date :
  1. Date Completed 2012-04-30
  2. Date Revised 2019-01-01
Further Info :

Pubmed ID

22135060

DOI: Digital Object Identifier

10.2146/ajhp110134

Related Literature

SNS
PICO Info
in preparation
Languages

English

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