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Anti-androgen effects of cypermethrin on the amino- and carboxyl-terminal interaction of the androgen receptor.

Author: HuJin-Xia, LiJing, LiYan-Fang, PanChen, WangHong-Mei, XuLi-Chun, ZhangJin-Peng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cypermethrin, a pyrethroid insecticide, was found to exhibit inhibitory effects on the androgen receptor (AR) N/C interaction, a mechanism required for the transcription potential of the AR.
Paper Details　
Original Abstract of the Article :
The pyrethroid insecticide, cypermethrin has been demonstrated to be an environmental anti-androgen in the androgen receptor (AR) reporter gene assay. The amino- and carboxyl-terminal (N/C) interaction is required for transcription potential of the AR. In order to characterize the anti-androgen effe...See full text at original site
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引用元：
https://doi.org/10.1016/j.tox.2011.11.019

データ提供：米国国立医学図書館（NLM）

Anti-androgen effects of cypermethrin on the amino- and carboxyl-terminal interaction of the androgen receptor

This research delves into the intriguing world of endocrine disruptors, chemicals that interfere with the body's hormone systems. It's like exploring a hidden oasis in the desert of endocrinology, where the balance of hormones is disrupted, leading to unforeseen consequences. The authors investigated the anti-androgen effects of cypermethrin, a widely used insecticide, on the androgen receptor (AR), a key protein involved in male sexual development. They found that cypermethrin exhibits anti-androgen activity, potentially interfering with the normal functioning of the AR.

A hidden oasis of disruption

This study sheds light on the potential risks of environmental chemicals on human health. It's like discovering a hidden oasis in the desert of endocrinology, where the delicate balance of hormones can be easily disrupted. The authors' findings provide a critical reminder of the importance of considering the potential impact of environmental chemicals on our health and well-being.

Navigating the desert of hormone health

This research emphasizes the importance of understanding the potential impact of environmental chemicals on our hormone systems. It's like being aware of the hidden dangers lurking in the desert, ensuring we take precautions to protect our hormonal balance. By remaining informed about the risks and potential consequences of exposure to endocrine disruptors, we can navigate the terrain of hormone health with greater awareness and precaution.

Dr. Camel's Conclusion

This study serves as a reminder that the desert of endocrinology is vast and complex, with unforeseen dangers lurking around every corner. By understanding the potential impact of environmental chemicals on our hormone systems, we can take steps to protect our health and navigate this terrain with greater awareness and precaution.
Date :
  1. Date Completed 2012-03-21
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

22172556

DOI: Digital Object Identifier

10.1016/j.tox.2011.11.019

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