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Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in bone.

Author: ChieffoNicole, EfstathiouEleni, HoangAnh, KarlouMaria, LogothetisChristopher J, MolinaArturo, SmithLisa A, TitusMark, TroncosoPatricia, TsavachidouDimitra, TzelepiVassiliki, WenSijin

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Abiraterone acetate achieved sustained suppression of testosterone in both blood and bone marrow aspirate to less than picograms-per-milliliter levels. Homogeneous, intense nuclear expression of androgen receptor (AR) combined with ≥ 10% CYP17 tumor expression was correlated with longer time to treatment discontinuation in patients with castrate-resistant prostate cancer (CRPC).
Paper Details　
Original Abstract of the Article :
PURPOSE: Persistent androgen signaling is implicated in castrate-resistant prostate cancer (CRPC) progression. This study aimed to evaluate androgen signaling in bone marrow-infiltrating cancer and testosterone in blood and bone marrow and to correlate with clinical observations. PATIENTS AND METHO...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295561/

データ提供：米国国立医学図書館（NLM）

Abiraterone Acetate: A Desert Oasis for Castrate-Resistant Prostate Cancer

The world of oncology is like a vast and unforgiving desert, where battling cancer is a constant struggle. This research delves into the treatment of castrate-resistant prostate cancer (CRPC), a particularly aggressive form of the disease. The study investigates the effectiveness of abiraterone acetate, a drug that blocks androgen synthesis, in patients with bone-metastatic CRPC.

Abiraterone Acetate: A Beacon of Hope in the Desert

The study found that abiraterone acetate effectively suppressed testosterone levels in both blood and bone marrow aspirate, suggesting its potential to effectively target androgen signaling in CRPC. This offers a promising therapeutic strategy for patients with this aggressive form of cancer. It’s like finding a beacon of hope in the desert of prostate cancer, offering a potential path towards a brighter future.

Fighting Prostate Cancer: A Desert Survival Guide

This research highlights the importance of targeting androgen signaling in the treatment of CRPC. It underscores the potential benefits of abiraterone acetate as a therapeutic agent for this disease, offering a valuable tool for oncologists in their fight against this challenging form of cancer. It’s like discovering a powerful weapon in the desert of prostate cancer, providing a means to combat this formidable foe.

Dr.Camel's Conclusion

This study provides compelling evidence of the effectiveness of abiraterone acetate in suppressing androgen signaling in castrate-resistant prostate cancer. It offers hope for patients with this aggressive form of cancer, demonstrating the potential of this drug to improve outcomes and prolong survival. It's like finding a precious oasis in the desert of prostate cancer, offering a lifeline for those who need it most.

Date :
  1. Date Completed 2012-04-30
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

22184395

DOI: Digital Object Identifier

PMC3295561

Related Literature

Article Analysis
・Effects of abiraterone
SNS
PICO Info
in preparation
Languages

English

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