Paper Details 
Original Abstract of the Article :
The international, phase III, multi-centre AZA-001 trial demonstrated azacitidine (AZA) is the first treatment to significantly extend overall survival (OS) in higher risk myelodysplastic syndromes (MDS) patients (Fenaux (2007) Blood110 817). The current treatment paradigm, which is based on a relat...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234059/

データ提供:米国国立医学図書館(NLM)

Exploring the Long-Term Effects of Azacitidine Treatment for Myelodysplastic Syndromes

The field of hematologic malignancies is a vast desert, often facing challenges in finding effective and lasting treatments for complex diseases. This study explores the long-term effects of azacitidine (AZA) treatment cycles on response in higher-risk myelodysplastic syndromes (MDS) patients. The researchers analyzed data from the AZA-001 trial, a phase III, multi-centre study that established AZA's efficacy in extending overall survival in higher-risk MDS patients. The study focuses on the relationship between response to AZA and survival, particularly examining the median number of AZA treatment cycles associated with achieving different response levels, including complete remission (CR), partial remission (PR), and hematological improvement (HI). The research sheds light on the long-term impact of AZA therapy and its potential to improve outcomes for MDS patients.

Azacitidine Demonstrates Long-Term Benefits for MDS Patients

This study provides valuable insights into the long-term effects of AZA treatment in higher-risk MDS patients. The research reveals that AZA therapy can significantly extend overall survival, with CR, PR, and HI all contributing to prolonged survival. The findings suggest that AZA therapy offers a promising treatment option for MDS patients, offering a potential path to improved outcomes and a longer lifespan.

A Beacon of Hope in the Desert of MDS Treatment

The study highlights the importance of long-term follow-up in evaluating the efficacy of cancer treatments. The research provides valuable insights into the long-term impact of AZA therapy on survival and response in higher-risk MDS patients. The findings offer a beacon of hope in the desert of MDS treatment, suggesting that AZA therapy can significantly improve outcomes for patients struggling with this challenging disease.

Dr.Camel's Conclusion

This study explores the long-term effects of azacitidine treatment cycles on response in higher-risk patients with myelodysplastic syndromes. The research demonstrates the potential of AZA therapy to extend overall survival and improve outcomes for MDS patients. The findings offer a beacon of hope in the desert of MDS treatment, suggesting that AZA therapy can significantly improve outcomes for patients struggling with this challenging disease.

Date :
  1. Date Completed 2012-05-02
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22275990

DOI: Digital Object Identifier

PMC3234059

Related Literature

SNS
PICO Info
in preparation
Languages

English

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