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Intralesional interferon therapy for basal cell carcinoma.

Author: AshworthS, CornellR C, EdwardsL, GreenwayH T, PeetsE A, SmilesK A, TannerD J, TaylorE L, TuckerS B, VanceJ C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Interferon alfa-2b, injected directly into basal cell carcinomas, was found to be an effective treatment, with an 86% cure rate compared to a 29% cure rate in the placebo group. Side effects, mainly flu-like symptoms, were mild and transient. One year after treatment, 81% of interferon recipients and 20% of those given the placebo remained tumor free.
Paper Details　
Original Abstract of the Article :
In a clinical trial of 172 patients at four medical centers, interferon alfa-2b (1.5 x 10(6) IU) or a placebo was injected directly into biopsy-proved noduloulcerative or superficial basal cell carcinomas three times weekly for 3 weeks, for a cumulative dose of 13.5 million IU. Efficacy of treatment...See full text at original site
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引用元：
https://doi.org/10.1016/0190-9622(90)70276-n

データ提供：米国国立医学図書館（NLM）

Intralesional Interferon Therapy: A Novel Approach for Basal Cell Carcinoma

Basal cell carcinoma (BCC) is a common type of skin cancer. This study explores the efficacy of intralesional interferon alfa-2b therapy as a treatment option for BCC.

Interferon alfa-2b's Effectiveness in Treating BCC

The researchers found that intralesional interferon alfa-2b therapy was significantly more effective than a placebo in treating noduloulcerative and superficial BCCs. They observed a high cure rate (86%) in the interferon-treated group compared to the placebo group (29%).

Side Effects and Long-Term Outcomes

The most common side effects of interferon treatment were flu-like symptoms, which were generally mild and transient. One year after the initiation of therapy, a significant proportion of interferon recipients (81%) remained tumor-free, compared to only 20% of those who received the placebo.

Dr.Camel's Conclusion

This study, like a skilled desert healer using natural remedies to treat a persistent ailment, offers a promising new approach to treating BCC. Intralesional interferon therapy appears to be a safe and effective option for some patients with BCC, providing a potential alternative to traditional surgical interventions.

Date :
  1. Date Completed 1990-12-04
  2. Date Revised 2019-07-09
Further Info :

Pubmed ID

2229497

DOI: Digital Object Identifier

10.1016/0190-9622(90)70276-n

Related Literature

Article Analysis
・Side Effects of interferon alfa-2b injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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