Paper Details

  1. Home
  2. Paper Details

Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.

Author: CzuczwarStanisław J, NieoczymDorota, SocałaKatarzyna, WlazPiotr, ŁuszczkiJarogniew J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of sildenafil, a PDE5 inhibitor, on seizure threshold and the anticonvulsant activity of various antiepileptic drugs (AEDs) in mice. Sildenafil did not affect seizure threshold but enhanced the anticonvulsant activity of ethosuximide (ETS) without affecting brain concentrations. This suggests potential benefits of combining sildenafil and ETS in male epileptic patients with erectile dysfunction.
Paper Details　
Original Abstract of the Article :
The aim of the present study was to investigate the effect of sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, on threshold for clonic seizures in mice. In addition, the effects of sildenafil on the anticonvulsant activity of selected antiepileptic drugs (AEDs), i.e., clonazepam (CZP), ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401299/

データ提供：米国国立医学図書館（NLM）

Sildenafil: A Potential Oasis for Epilepsy Treatment?

The world of [epilepsy] is a vast desert of research, with scientists tirelessly seeking new and effective treatments. This study explores the potential interaction between [sildenafil], a drug primarily known for treating [erectile dysfunction], and various [antiepileptic drugs (AEDs)]. The authors delved into the complexities of these interactions, using animal models to investigate how sildenafil might impact the anticonvulsant effects of AEDs. Their findings suggest that sildenafil may enhance the effectiveness of [ethosuximide] in reducing seizures without causing adverse side effects.

Sildenafil and Ethosuximide: A Serendipitous Oasis in the Desert of Epilepsy Treatment

The study found that sildenafil did not directly affect seizure susceptibility but significantly enhanced the anticonvulsant activity of [ethosuximide] in mice. This suggests that combining sildenafil with [ethosuximide] could potentially improve seizure control in patients.

Navigating the Desert of Epilepsy Treatment: A New Path Forward?

This research opens up new avenues for exploring the potential of drug repurposing in epilepsy treatment. While further research is needed to confirm these findings in human trials, the study suggests that sildenafil may offer a promising therapeutic option for individuals with epilepsy.

Dr.Camel's Conclusion

This research reminds us that the desert of medical science often holds hidden treasures. By exploring the potential interactions between seemingly unrelated drugs, we can uncover new therapeutic possibilities for conditions like epilepsy.

Date :
  1. Date Completed 2012-11-29
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22315091

DOI: Digital Object Identifier

PMC3401299

Related Literature

Article Analysis
・Side Effects of ethosuximide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.