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Degradation of the tricyclic antipsychotic drug chlorpromazine under environmental conditions, identification of its main aquatic biotic and abiotic transformation products by LC-MSn and their effects on environmental bacteria.

Author: KümmererKlaus, TrautweinChristoph

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study explored the environmental transformation of chlorpromazine, a tricyclic antipsychotic drug, through various pathways, including aerobic and anaerobic biodegradation and photolytic degradation. A total of 61 abiotic and biotic transformation products were identified. The study suggests that chlorpromazine is not biodegradable but undergoes transformation into various products that are likely to persist in the aquatic environment.
Paper Details　
Original Abstract of the Article :
The search for environmental transformation products of organic pollutants (like drugs) is a difficult task and usually only few compounds are detected. This might be due to effective degradation but could also be a result of analytical deficits dealing with complex matrices. Especially transformati...See full text at original site
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引用元：
https://doi.org/10.1016/j.jchromb.2012.01.022

データ提供：米国国立医学図書館（NLM）

Chlorpromazine: A Desert Mystery Unveiled

Chlorpromazine, a widely used antipsychotic medication, is like a mysterious desert mirage, its environmental fate largely unknown. This study takes a deep dive into the transformation of chlorpromazine in different environments, identifying a surprisingly diverse array of transformation products. Imagine these products as hidden oases in the desert, each with its own unique characteristics and potential effects. The study found that chlorpromazine undergoes both biotic and abiotic transformations, with a total of 61 products identified. This research sheds light on the complexity of environmental fate for pharmaceuticals, revealing a hidden ecosystem of transformation products that could have implications for environmental health.

The Desert Unveiled: Understanding the Environmental Fate of Chlorpromazine

This research uncovers the surprising complexity of chlorpromazine's environmental fate. It highlights the importance of understanding the transformation of pharmaceuticals in different environments to assess their potential risks. Imagine this research as a map, revealing the hidden pathways and oases of transformation products, guiding us toward a better understanding of their impact on the environment.

Navigating the Desert: Ensuring Environmental Safety

The study emphasizes the need for ongoing research to evaluate the ecotoxicological properties of chlorpromazine and its transformation products. It highlights the importance of understanding the environmental fate of pharmaceuticals and ensuring their safe use. Just as a camel navigates the desert with caution, we must carefully consider the potential risks of pharmaceuticals and their impact on the environment.

Dr. Camel's Conclusion

This study reveals the hidden complexities of chlorpromazine's environmental fate, uncovering a vast desert of transformation products. It reminds us that even seemingly simple substances can have unexpected environmental impacts. We must continue to explore these hidden oases, seeking knowledge and understanding to ensure a sustainable future.

Date :
  1. Date Completed 2012-07-17
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

22342447

DOI: Digital Object Identifier

10.1016/j.jchromb.2012.01.022

Related Literature

Article Analysis
・Effects of chlorpromazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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