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Changes caused by haloperidol are blocked by music in Wistar rat.

Author: García-MayórgazÁngel D, MontillaPedro, QueroIsmael, TassetInmaculada, TúnezIsaac, del RíoManuel Causse

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study investigated the effects of classical music on dopamine levels in the brain and hormone secretion in rats. Exposure to music led to increased dopamine levels in all brain regions studied, particularly in the prefrontal cortex and striatal nucleus. Music also reduced prolactin and corticosterone levels, suggesting a potential mood-regulating effect.
Paper Details　
Original Abstract of the Article :
This study sought to evaluate the effect of classical music, using Mozart's sonata for two pianos (K. 448), on changes in dopamine (DA) levels in the striatal nucleus (SN), prefrontal cortex (PFC) and mesencephalon, and on prolactin (PRL) and corticosterone secretion in adult male Wistar rats. Rats ...See full text at original site
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引用元：
https://doi.org/10.1007/s13105-011-0129-8

データ提供：米国国立医学図書館（NLM）

Music's Impact on Haloperidol-Induced Changes in the Brain

This study delves into the intriguing interaction between music and the brain, specifically focusing on the effects of classical music on dopamine levels and hormone secretion in rats treated with haloperidol, a drug used to treat psychosis. The researchers found that exposure to Mozart's sonata for two pianos (K. 448) significantly increased dopamine levels in the brain, countered the effects of haloperidol on prolactin and corticosterone levels, and also reduced these hormone levels in healthy rats.

Music: A Potential Modulator of Dopamine and Hormone Levels

This study suggests that music can have a significant impact on dopamine activity and hormone levels in the brain. It found that exposure to classical music increased dopamine levels and counteracted the effects of haloperidol on prolactin and corticosterone levels.

Exploring the Therapeutic Potential of Music

The study's findings raise the intriguing possibility of music therapy as a potential therapeutic tool for mental health conditions. Further research is needed to explore the mechanisms by which music affects dopamine levels and hormone secretion and to investigate its potential clinical applications.

Dr. Camel's Conclusion

This study demonstrates the potential of music as a modulator of dopamine and hormone levels in the brain. It opens the door to further research into the therapeutic potential of music, potentially paving the way for new approaches to treating mental health conditions.
Date :
  1. Date Completed 2012-08-30
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22371013

DOI: Digital Object Identifier

10.1007/s13105-011-0129-8

Related Literature

Article Analysis
・Effects of haloperidol injection
SNS
PICO Info
in preparation
Languages

English

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