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Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.

Author: AlamuddinNaji, CrichtonIrene, FitzGeraldGarret A, IbrahimSalam, LawsonJohn A, PrempehMaxwell, PuréEllen, RasmussenLars Melholt, RicciottiEmanuela, SongWen-Liang, StubbeJane, WilenskyRobert L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the cardiovascular biology of PGD₂ and its role in niacin-induced flushing. The authors show that PGD₂ biosynthesis is augmented during platelet activation in humans and that PGD₂ may function as a homeostatic response to thrombogenic and hypertensive stimuli, particularly during niacin therapy.
Paper Details　
Original Abstract of the Article :
The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1-dependent formation of PGD₂ and PGE₂ followed by COX-2-dependent production of PGE₂. Consistent with this, niacin-induced...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314457/

データ提供：米国国立医学図書館（NLM）

Niacin and Biosynthesis of PGD₂ by Platelet COX-1

The study of [niacin] and its effects on the body is a complex and fascinating field, with a growing understanding of its role in [lipid metabolism] and [cardiovascular health]. This research delves into the intricate world of [platelet biology] and examines the impact of niacin on the production of [PGD₂] by [platelet COX-1]. The researchers employed a combination of [experimental] and [clinical] studies to investigate the mechanisms underlying niacin's effects.

The Complex Effects of Niacin

The study revealed that niacin, a common lipid-lowering drug, significantly impacts the production of [PGD₂] by platelets, highlighting a potential role for this prostaglandin in [thrombogenesis] and [hypertension]. This is like observing the intricate web of interactions within a desert ecosystem, where one change in a species can cascade through the entire system. The study's findings suggest that PGD₂ may play a significant role in maintaining cardiovascular health.

Implications for Niacin Therapy

The study's findings have important implications for the use of niacin in clinical practice. The researchers emphasize the importance of considering the potential effects of niacin on platelet function and cardiovascular health, particularly in individuals with pre-existing cardiovascular conditions. This is like carefully navigating a desert landscape, understanding the potential risks and benefits of each path before making a decision. This research provides valuable insights for healthcare professionals to optimize niacin therapy and minimize potential adverse effects.

Dr.Camel's Conclusion

This research, like a desert oasis offering a respite from the harshness of the environment, sheds light on the complex effects of niacin on platelet biology and cardiovascular health. The study highlights the importance of considering the potential impact of niacin on platelet function and emphasizes the need for individualized treatment strategies to optimize patient outcomes. Like a skilled desert explorer, healthcare professionals must navigate the complex landscape of niacin therapy, carefully weighing the potential benefits and risks to ensure the best possible outcomes for their patients.

Date :
  1. Date Completed 2012-07-06
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22406532

DOI: Digital Object Identifier

PMC3314457

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Languages

English

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